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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 98 - 103 (6page)
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Recurrence is a serious problem in patients with bladder cancer. The hypothesis for recurrence was that the proliferation of drug-resistant cells was reported, and this study focused on drug resistance due to drug efflux. Previous studies have identified FOXM1 as the key gene for recurrence. We found that FOXM1 inhibition decreased drug efflux activity and increased sensitivity to Doxorubicin. Therefore, we examined whether the expression of ABC transporter gene related to drug efflux is regulated by FOXM1. As a result, ABCG2, one of the genes involved in drug efflux, has been identified as a new target for FOXM1. We also demonstrated direct transcriptional regulation of ABCG2 by FOXM1 using ChIP assay. Consequently, in the presence of the drug, FOXM1 is proposed to directly activate ABCG2 to increase the drug efflux activation and drug resistance, thereby involving chemoresistance of bladder cancer cells. Therefore, we suggest that FOXM1 and ABCG2 may be useful targets and important parameters in the treatment of bladder cancer.
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참고문헌 (31)
참고문헌 신청
Torre LA / 2015 / Global cancer statistics,2012 / CA Cancer J Clin 65:87~108
Youssef RF / 2011 / Predictors of outcome of non-muscle-invasive and muscle-invasive bladder cancer / ScientificWorldJournal 11:369~381
Sylvester RJ / 2006 / Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: a combined analysis of 2596 patients from seven EORTC trials / Eur Urol 49:466~465
Hall MC / 2007 / Guideline for the management of nonmuscle invasive bladder cancer (stages Ta, T1, and Tis): 2007 update / J Urol 178:2314~2330
Woldu SL / 2017 / Guideline of guidelines: non-muscle-invasive bladder cancer / BJU Int 119:371~380
Youssef RF / 2011 / Predictors of outcome of non-muscle-invasive and muscle-invasive bladder cancer / ScientificWorldJournal 11:369~381
Sylvester RJ / 2006 / Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: a combined analysis of 2596 patients from seven EORTC trials / Eur Urol 49:466~465
Hall MC / 2007 / Guideline for the management of nonmuscle invasive bladder cancer (stages Ta, T1, and Tis): 2007 update / J Urol 178:2314~2330
Woldu SL / 2017 / Guideline of guidelines: non-muscle-invasive bladder cancer / BJU Int 119:371~380
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