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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 943 - 952 (10page)
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The discovery and mechanistic understanding of targetspecific genome engineering technologies has led to extremely effective and specific genome editing in higher organisms. Target-specific genetic modification technology is expected to have a leading position in future gene therapy development, and has a ripple effect on various basic and applied studies. However, several problems remain and hinder efficient and specific editing of target genomic loci. The issues are particularly critical in precise targeted insertion of external DNA sequences into genomes. Here, we discuss some recent efforts to overcome such problems and present a perspective of future genome editing technologies.
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참고문헌 (73)
참고문헌 신청
[학술지(정기간행물)] - Aird, E. J. / 2018 / Increasing Cas9-mediated homology-directed repair efficiency through covalent tethering of DNA repair template / Commun. Biol 1
[학술지(정기간행물)] - Auer, T. O. / 2014 / Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair / Genome Res 24 : 142 ~ 153
[학술지(정기간행물)] - Bae, S. / 2014 / Microhomologybased choice of Cas9 nuclease target sites / Nat. Methods 11 : 705 ~ 706
[학술지(정기간행물)] - Bee, L. / 2013 / The efficiency of homologous recombination and non-homologous end joining systems in repairing double-strand breaks during cell cycle progression / PLoS One 8 : e69061
[학술지(정기간행물)] - Braff, J. L. / 2016 / Characterization of Cas9-Guide RNA orthologs / Cold Spring Harb. Protoc
[학술지(정기간행물)] - Auer, T. O. / 2014 / Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair / Genome Res 24 : 142 ~ 153
[학술지(정기간행물)] - Bae, S. / 2014 / Microhomologybased choice of Cas9 nuclease target sites / Nat. Methods 11 : 705 ~ 706
[학술지(정기간행물)] - Bee, L. / 2013 / The efficiency of homologous recombination and non-homologous end joining systems in repairing double-strand breaks during cell cycle progression / PLoS One 8 : e69061
[학술지(정기간행물)] - Braff, J. L. / 2016 / Characterization of Cas9-Guide RNA orthologs / Cold Spring Harb. Protoc
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