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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 153 - 159 (7page)
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Dasatinib, a tyrosine kinase inhibitor, is widely used for patients with chronic myeloid leukemia and Philadelphia chromosome- positive acute lymphoblastic leukemia. Although the drug has a potent immunosuppressive effect, infectious complications during dasatinib treatment have been reported rarely. We describe five patients who developed cytomegalovirus (CMV) colitis during dasatinib treatment, in whom the colitis was initially confused with other causes. The patients, three with chronic myeloid leukemia, and two with acute lymphoblastic leukemia, were diagnosed with CMV colitis based on endoscopic and histologic findings. The patients who examined blood CMV polymerase chain reaction were all positive. The patients received antiviral therapy in the form of either ganciclovir or valganciclovir, and the overall treatment outcome was fair. These cases suggest that physicians should consider the possibility of CMV reactivation when treating diarrhea and/or hematochezia in patients on dasatinib.
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참고문헌 (17)
참고문헌 신청
Schade AE / 2008 / Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation / Blood 111:1366~1377
Baccarani M / 2009 / Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet / J Clin Oncol 27:6041~6051
Ottmann O / 2007 / Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study / Blood 110:2309~2315
de la Hoz RE / 2002 / Diagnosis and treatment approaches of CMV infections in adult patients / J Clin Virol 25(Suppl 2):S1~S12
Kmira Z / 2013 / Severe hemorrhagic colitis in a patient with chronic myeloid leukemia in the blastic phase after dasatinib use / World J Gastrointest Pathophysiol 4:59~62
Baccarani M / 2009 / Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet / J Clin Oncol 27:6041~6051
Ottmann O / 2007 / Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study / Blood 110:2309~2315
de la Hoz RE / 2002 / Diagnosis and treatment approaches of CMV infections in adult patients / J Clin Virol 25(Suppl 2):S1~S12
Kmira Z / 2013 / Severe hemorrhagic colitis in a patient with chronic myeloid leukemia in the blastic phase after dasatinib use / World J Gastrointest Pathophysiol 4:59~62
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