지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 160 - 165 (6page)
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초록· 키워드
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Background: Extended-spectrum ß-lactamase-producing Enterobacteriaceae (ESBL-PE) are increasingly reported as pathogens in urinary tract infections (UTIs). However, in Sri Lanka, the clinical and molecular epidemiology of ESBL-PE implicated in UTIs has not been well described.
Materials and Methods: We conducted prospective, laboratory-based surveillance from October to December 2013 at a tertiary care hospital in southern Sri Lanka and enrolled patients ≥1 year of age with clinically relevant UTIs due to ESBL-PE. Isolate identity, antimicrobial drug susceptibility, and ESBL production were determined. Presence of ß-lactamase genes, blaSHV, blaTEM, and blaCTX-M, was identified by polymerase chain reaction.
Results: During the study period, Enterobacteriaceae were detected in 184 urine samples, with 74 (40.2%) being ESBL producers.
Among 47 patients with ESBL-PE who had medical records available, 38 (80.9%) had clinically significant UTIs. Most UTIs (63.2%) were community acquired and 34.2% were in patients with diabetes. Among 36 cultured ESBL-PE isolates, significant susceptibility (>80%) was only retained to amikacin and the carbapenems. The group 1 blaCTX-M gene was present in 90.0% of Escherichia coli isolates and all Klebsiella pneumoniae and Enterobacter cloacae isolates. The blaSHV and blaTEM genes were more common in K. pneumoniae (75% and 50%) and E. cloacae (50% and 50%) isolates than in E. coli (10% and 20%) isolates, respectively.
Conclusion: The majority of UTIs caused by ESBL-PE were acquired in the community and due to organisms carrying the group 1 CTX-M ß-lactamase. Further epidemiologic studies of infections due to ESBL-PE are urgently needed to better prevent and treat these infections in South Asia.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Livermore DM / 2012 / Fourteen years in resistance / Int J Antimicrob Agents 39:283~294
Wellington EM / 2013 / The role of the natural environment in the emergence of antibiotic resistance in gram-negative bacteria / Lancet Infect Dis 13:155~165
Hammami S / 2013 / Characterization of extended spectrum β-lactamase-producing Escherichia coli in community-acquired urinary tract infections in Tunisia / Microb Drug Resist 19:231~236
Lau SM / 2004 / Resistance rates to commonly used antimicrobials among pathogens of both bacteremic and non-bacteremic community-acquired urinary tract infection / J Microbiol Immunol Infect 37:185~191
Meier S / 2011 / Extended-spectrum β-lactamase-producing Gram-negative pathogens in community-acquired urinary tract infections: an increasing challenge for antimicrobial therapy / Infection 39:333~340
Wellington EM / 2013 / The role of the natural environment in the emergence of antibiotic resistance in gram-negative bacteria / Lancet Infect Dis 13:155~165
Hammami S / 2013 / Characterization of extended spectrum β-lactamase-producing Escherichia coli in community-acquired urinary tract infections in Tunisia / Microb Drug Resist 19:231~236
Lau SM / 2004 / Resistance rates to commonly used antimicrobials among pathogens of both bacteremic and non-bacteremic community-acquired urinary tract infection / J Microbiol Immunol Infect 37:185~191
Meier S / 2011 / Extended-spectrum β-lactamase-producing Gram-negative pathogens in community-acquired urinary tract infections: an increasing challenge for antimicrobial therapy / Infection 39:333~340
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