지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 197 - 204 (8page)
이용수
초록· 키워드
오류제보하기
MicroRNA (miRNA, miR) is essential in regulating cell differentiation either by inhibiting mRNA translation or by inducing its degradation. However, the role of miRNA in odontoblastic cell differentiation is still unclear. In this study, we examined the molecular mechanism of miR-27-mediated regulation of odontoblast differentiation in MDPC-23 mouse odontoblastic cells derived from mouse dental papilla cells.
The results of the present study demonstrated that the miR-27 expression increases significantly during MDPC-23 odontoblastic cell differentiation. Furthermore, miR-27 up-regulation promotes the differentiation of MDPC-23 cells and accelerates mineralization without cell proliferation. The over-expression of miR-27 significantly increased the expression levels of Wnt1 mRNA and protein. In addition, the results of target gene prediction revealed that Wnt1 mRNA has an miR-27 binding site in its 3’UTR, and is increased by miR-27. These results suggested that miR-27 promotes MDPC-23 odontoblastic cell differentiation by targeting Wnt1 signaling. Therefore, miR-27 is a critical odontoblastic differentiation molecular target for the development of miRNA based therapeutic agents in dental medicine.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Carrington JC / 2003 / Role of microRNAs in plant and animal development / Science 301 : 336 ~ 338
H. Liu / 2013 / miR-145 and miR-143 Regulate Odontoblast Differentiation through Targeting Klf4 and Osx Genes in a Feedback Loop / Journal of Biological Chemistry 288 (13) :
I. Bentwich / 2005 / A postulated role for microRNA in cellular differentiation / The FASEB Journal 19 (8) : 875 ~ 879
J. M. Romao / 2011 / MicroRNA regulation in mammalian adipogenesis / Experimental Biology and Medicine 236 (9) : 997 ~ 1004
Jue Feng / 2009 / MicroRNA-27 enhances differentiation of myeloblasts into granulocytes by post-transcriptionally downregulating Runx1 / British Journal of Haematology 145 (
H. Liu / 2013 / miR-145 and miR-143 Regulate Odontoblast Differentiation through Targeting Klf4 and Osx Genes in a Feedback Loop / Journal of Biological Chemistry 288 (13) :
I. Bentwich / 2005 / A postulated role for microRNA in cellular differentiation / The FASEB Journal 19 (8) : 875 ~ 879
J. M. Romao / 2011 / MicroRNA regulation in mammalian adipogenesis / Experimental Biology and Medicine 236 (9) : 997 ~ 1004
Jue Feng / 2009 / MicroRNA-27 enhances differentiation of myeloblasts into granulocytes by post-transcriptionally downregulating Runx1 / British Journal of Haematology 145 (
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effect of Metformin on Cell Growth and Differentiation in Cultured Odontoblasts
International Journal of Oral Biology
2017 .01
-
Effect of Resveratrol on Cell Differentiation and Mineralization in Cultured Odontoblasts
International Journal of Oral Biology
2018 .01
-
Down Regulation of miR-34a and miR-143 May Indirectly Inhibit p53 in Oral Squamous Cell Carcinoma: a Pilot Study
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
A novel panel of serum miR-21/miR-155/miR-365 as a potential diagnostic biomarker for breast cancer
Annals of Surgical Treatment and Research
2017 .02
-
Investigation of Dysregulation of Several MicroRNAs in Peripheral Blood of Schizophrenia Patients
Clinical Psychopharmacology and Neuroscience
2016 .01
-
miR-196b-5p and miR-375 Expression in Gastric Cancer
대한임상종양학회 학술대회지
2016 .02
-
MiR-1246 Promotes Metastasis and Invasion of A549 Cells by Targeting GSK-3β–Mediated Wnt/β-Catenin Pathway
Cancer Research and Treatment
2019 .01
-
Regulation of Colonic Mucosal MicroRNA Expression via Multiple Targets in Visceral Hypersensitivity Rats by Tongxieyaofang
Yonsei Medical Journal
2018 .01
-
Circulating Plasma Micro RNAs in Patients with Major Depressive Disorder Treated with Antidepressants: A Pilot Study
PSYCHIATRY INVESTIGATION
2016 .01
-
MiR-675 Promotes the Growth of Hepatocellular Carcinoma Cells Through Cdc25A Pathway
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Expression of specific microRNAs in tissue and plasma in colorectal cancer
Journal of Pathology and Translational Medicine
2023 .05
-
MicroRNA Expression in Plasma of Esophageal Squamous Cell Carcinoma Patients
Journal of Korean Medical Science
2022 .06
-
Expression of miR-221 and miR-18a in patients with hepatocellular carcinoma and its clinical significance
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2022 .06
-
miR-34a Inhibitor May Effectively Protect against Sevoflurane-Induced Hippocampal Apoptosis through the Wnt/β-Catenin Pathway by Targeting Wnt1
Yonsei Medical Journal
2018 .01
-
Upregulation of miR-27b Facilitates Apoptosis of TNF-α-Stimulated Fibroblast-Like Synoviocytes
Yonsei Medical Journal
2019 .01
-
miR-195/miR-497 Regulate CD274 Expression of Immune Regulatory Ligands in Triple-Negative Breast Cancer
Journal of Breast Cancer
2018 .01
-
Peripheral Signatures of Psychiatric Disorders: MicroRNAs
Clinical Psychopharmacology and Neuroscience
2017 .01
-
Combined Detection of Serum MiR-221-3p and MiR-122-5p Expression in Diagnosis and Prognosis of Gastric Cancer
Journal of Gastric Cancer
2019 .01
-
MiR-92a-1-5p and miR-328-3p Are Up-Regulated in Skin of Female Pattern Hair Loss Patients
Annals of Dermatology
2019 .01
-
Time-course changes in the expression levels of miR-122, -155, and -21 as markers of liver cell damage, inflammation, and regeneration in acetaminophen-induced liver injury in rats
Journal of Veterinary Science
2016 .03
이 논문의 저자 정보
최근 본 자료
댓글(0)
0