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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 63 - 69 (7page)
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Curcumin (diferuloylmethane), a constituent of turmeric powder derived from the rhizome of Curcuma longa, has been shown to inhibit the growth of various types of cancer cells by regulating cell proliferation and apoptosis. However, a need exists to design more effective analogs because of curcumin's poor intestinal absorption. EF-24 (diphenyl difluoroketone), the monoketone analog of curcumin, has shown good efficacy in anticancer screens. However, the effects of curcumin and EF-24 on salivary gland epidermoid carcinoma cells are not clearly established. The main goal of this study was to investigate the effects of curcumin and EF-24 on cell growth and induction of apoptosis in human salivary gland epidermoid carcinoma cells. Our studies showed that curcumin and EF-24 inhibited the growth of HTB-41 cells in a dose- and time-dependent manner, and the potency of EF-24 was > 34-fold that of curcumin. Treatment with curcumin or EF-24 resulted in nuclear condensation and fragmentation in HTB-41 cells, whereas the control HTB-41 cell nuclei retained their normal regular and oval shape. Curcumin and EF-24 promoted proteolytic cleavages of procaspase-3/-7/-9, resulting in an increase in the amount of cleaved caspase-3/-7/-9 in the HTB-41 cells. Caspase-3 and -7 activities were detected in viable HTB-41 cells treated with curcumin or EF-24. These results suggest that the curcumin and EF-24 inhibit cell proliferation and induce apoptosis in HTB-41 human salivary gland epidermoid carcinoma cells, and that they may have potential properties as an anti-cancer drug therapy.
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참고문헌 (40)
참고문헌 신청
Ajay Goel / 2008 / Curcumin as “Curecumin”: From kitchen to clinic / Biochemical Pharmacology 75(4):787~809
Preetha Anand / 2007 / Bioavailability of Curcumin: Problems and Promises / Molecular Pharmaceutics 4(6):807~818
Brian K. Adams / 2004 / Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents / Bioorganic & Medicinal Chemistry 12(14):3871~3883
Adams BK / 2005 / EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redoxdependent mechanism / Anticancer Drugs 16:263~275
Myoung-Hwa Lee / 2010 / Ethanol Extracts of Angelica decursiva Induces Apoptosis in Human Oral Cancer Cells / International Journal of Oral Biology 35(4):215~220
Preetha Anand / 2007 / Bioavailability of Curcumin: Problems and Promises / Molecular Pharmaceutics 4(6):807~818
Brian K. Adams / 2004 / Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents / Bioorganic & Medicinal Chemistry 12(14):3871~3883
Adams BK / 2005 / EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redoxdependent mechanism / Anticancer Drugs 16:263~275
Myoung-Hwa Lee / 2010 / Ethanol Extracts of Angelica decursiva Induces Apoptosis in Human Oral Cancer Cells / International Journal of Oral Biology 35(4):215~220
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