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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 177 - 183 (7page)
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초록· 키워드
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The objective of this study was to examine the expression pattern of Kelch-like ECH-associated protein 1 (Keap1) in the maxillary 2 nd molar germs of rats. We used the maxillary 2 nd molar germs in rats’ pup at postnatal day 3 (bell stage), 6 (crown formation stage) and 9 (root formation stage). The investigation on mRNA and protein levels were done using reverse transcription - polymerase chain reaction and western blot. Localization of Keap 1 in the maxillary 2 nd molar germs were revealed through immunofluorescence staining. Keap1 from the maxillary 2nd molar germs were mostly manifested on postnatal day 3 and dramatically decreased on postnatal day 6 and 9 at mRNA and protein levels, while amelogenin and ameloblastin increased during the development of maxillary 2nd molar germs. During immunofluorescence analysis, the strong immunoreactivity against Keap1 was detected in the apical side of ameloblasts at the presecretory and secretory stages. However, Keap1 expression was hardly observed in the ameloblasts at the maturation stage. These results shows that Keap1 is strongly expressed in the presecretory and secretory ameloblasts of amelogenesis, and suggest that Keap1 may be a crucial molecule for the regulatory mechanisms tasked with the formation of enamel layer.
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참고문헌 (26)
참고문헌 신청
Kollar EJ / 1991 / Role of the early epithelium in the patterning of the teeth and Meckel’s cartilage / J Craniofac Genet Dev Biol 11:223~228
Slavkin HC / 1991 / Molecular determinants during dental morphogenesis and cytodifferentiation: a review / J Craniofac Gen Dev Biol 11:338~349
Thesleff I / 2003 / Epithelial–mesenchymal signaling regulating tooth morphogenesis / J Cell Sci 116:1647~1648
Pispa J / 2003 / Mechanisms of ectodermal organogenesis / Dev Biol 262:195~205
Simmer JP / 2010 / Regulation of dental enamel shape and hardness / J Dent Res 89:1024~1038
Slavkin HC / 1991 / Molecular determinants during dental morphogenesis and cytodifferentiation: a review / J Craniofac Gen Dev Biol 11:338~349
Thesleff I / 2003 / Epithelial–mesenchymal signaling regulating tooth morphogenesis / J Cell Sci 116:1647~1648
Pispa J / 2003 / Mechanisms of ectodermal organogenesis / Dev Biol 262:195~205
Simmer JP / 2010 / Regulation of dental enamel shape and hardness / J Dent Res 89:1024~1038
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