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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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The eruptive movement of tooth germs in the alveolar bone is supposed to be timely regulated by molecules that involve the differentiation of osteoclasts for preparing a tooth eruption pathway. Thus, the detection of the molecules is the first to understand the movement.
This study hypothesized that molecules are expressed differentially from tooth germs themselves with follicles in eruptive movement. To verify this, genes were detected in rat molar germs using differential display-PCR. The localization and expression of the detected molecules were evidenced by immunofluorescence, and real-time PCR, and western blot, respectively. Osteoprotegerin was one of the differentially expressed molecules between the cap stage (third molar germs before the eruptive movement) and the root formation stage (2nd molar germs after the eruptive movement) at postnatal day nine. Osteoprotegerin was localized in follicular and perifollicular tissues, which are overlaying developing the third molar germs. The osteoprotegerin expression was downregulated from day three to nine in a time dependent manner, followed by the upregulation at day 12. In contrast, receptor activator of nuclear factor kappa-Β ligand was expressed strongly in follicular tissues overlaying the second molar germs, and up-regulated in time-dependently. The treatment of alendronate, a second-generation bisphosphonate for nine days, revealed the upregulation of osteoprotegerin and downregulation of receptor activator of nuclear factor kappa-Β ligand.
These results suggest that dental follicles may control the eruptive movement of tooth germs by regulating receptor activator of nuclear factor kappa-Β ligand and osteoprotegerin expression in dental follicles.
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참고문헌 (28)
참고문헌 신청
Grier RL / 1998 / Inhibition of tootheruption in the rat by a bisphosphonate / J Dent Res 77(1):8~15
Marks SJ / 1995 / The mechanisms and mediators of tooth eruption-models for developmental biologists / Int J Dev Biol 39(1):223~230
Niida S / 1997 / Restoration of disturbed tooth eruption in osteopetrotic (op/op) mice by injection of macrophage colony-stimulating factor / Exp Anim 46(2):95~101
Wise GE / 1998 / In vivo effect of IL-1a on CSF-1 gene expression in the dental follicle of the rat molar / Arch Oral Biol 43(2):163~165
Ta-i Iizuka / 1992 / The effects of colony-stimulating factor-1 on tooth eruption in the toothless (osteopetrotic) rat in relation to the critical periods for bone resorption during tooth eruption / Archives of Oral Biology 37(8):629~636
Marks SJ / 1995 / The mechanisms and mediators of tooth eruption-models for developmental biologists / Int J Dev Biol 39(1):223~230
Niida S / 1997 / Restoration of disturbed tooth eruption in osteopetrotic (op/op) mice by injection of macrophage colony-stimulating factor / Exp Anim 46(2):95~101
Wise GE / 1998 / In vivo effect of IL-1a on CSF-1 gene expression in the dental follicle of the rat molar / Arch Oral Biol 43(2):163~165
Ta-i Iizuka / 1992 / The effects of colony-stimulating factor-1 on tooth eruption in the toothless (osteopetrotic) rat in relation to the critical periods for bone resorption during tooth eruption / Archives of Oral Biology 37(8):629~636
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