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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 137 - 142 (6page)
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초록· 키워드
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To determine the effect of the tumor necrosis factor-α (TNF-α) in odontoclast formation, we administrated a TNF-α inhibitor in rats with diabetes rats with periodontitis. The rats included in the study were divided into three groups: control rats without diabetes or periodontitis (the C group), rats with periodontitis and diabetes (the PD group), and rats with periodontitis and diabetes treated by infliximab, the TNF inhibitor (the PD+infliximab group). The PD and PD+ infliximab groups received intravenous administrations of streptozotocin (STZ, 50 mg/kg) to induce diabetes. After 7 days of STZ injections, the mandibular first molars were ligatured to induce periodontitis. The PD+infliximab group was intrapenitoneally administrated by infliximab (5 mg/kg).
On days 3 and 20 after the ligature administration, odontoclast formation along root surfaces was evaluated by tartrate resistant acid phosphatase (TRAP) staining and cathepsin K immunohistochemistry. On day 3, the number of TRAP- and cathepsin K-positive cells increased more so in the PD group than in the C group. The PD+infliximab group showed a lower number of positive cells than the PD group. There was no difference in all the groups on day 20. On day 3, the cathepsin-K positive multinucleated and mononucleated cells were higher in the PD group than in the C group. The number of cathepsin-K positive multinucleated cells was lower in the PD+infliximab group than in the PD group. The PD group showed more cathepsin K-positive cells in the furcation and distal surfaces than the c group. The Cathepsin K-positive cells of the PD+infliximab group were lower than that of the PD group in furcation. These results suggest that TNF-α stimulates odontoclast formation in diabetes with periodontitis.
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참고문헌 (21)
참고문헌 신청
A. Iglesias-Linares / 2016 / Cellular and Molecular Pathways Leading to External Root Resorption / Journal of Dental Research 96 (2) : 145 ~ 152
Antonio Crespo Abelleira / 1999 / Morphological Study of Root Surfaces in Teeth With Adult Periodontitis / Journal of Periodontology 70 (11) : 1283 ~ 1291
B.F. Boyce / 2013 / Advances in the Regulation of Osteoclasts and Osteoclast Functions / Journal of Dental Research 92 (10) : 860 ~ 867
B.L.C. Harvey / 1959 / Root surface resorption of periodontally diseased teeth / Oral Surgery, Oral Medicine, Oral Pathology 12 (12) : 1439 ~ 1443
Bouchra Sojod / 2017 / RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model / Frontiers in Physiology 8 : 338 ~
Antonio Crespo Abelleira / 1999 / Morphological Study of Root Surfaces in Teeth With Adult Periodontitis / Journal of Periodontology 70 (11) : 1283 ~ 1291
B.F. Boyce / 2013 / Advances in the Regulation of Osteoclasts and Osteoclast Functions / Journal of Dental Research 92 (10) : 860 ~ 867
B.L.C. Harvey / 1959 / Root surface resorption of periodontally diseased teeth / Oral Surgery, Oral Medicine, Oral Pathology 12 (12) : 1439 ~ 1443
Bouchra Sojod / 2017 / RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model / Frontiers in Physiology 8 : 338 ~
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