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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 205 - 213 (9page)
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초록· 키워드
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The mechanisms underlying the actions of the antioxidantsupon reactive oxygen species (ROS) generation byNADPH oxidase complex have remained uncertain. In thisstudy, we investigated NADPH oxidase activity and the roleof antioxidant enzymes upon the generation of ROS duringhypoxic stress. ROS generation was found to increase in themouse kidney under hypoxic stress in a time-dependentmanner. Moreover, we found in MCT cells that hypoxiainducedhydrogen peroxide production was decreased byNAC pretreatment. We further analyzed HIF-1α, PHD2and VHL expression in the NAC-pretreated MCT cells andassessed the response of antioxidant enzymes at the transcriptionaland translational levels. SOD3 and Prdx2 weresignificantly increased during hypoxia in the mouse kidney.
We also confirmed in hypoxic Prdx2-/-and SOD3 transgenicmice that erythropoietin (EPO) is transcriptionally regulatedby HIF-1α. In addition, although EPO protein was found tobe expressed in a HIF-1α independent manner in threemouse lines, its activity differed markedly between normaland Prdx2-/-/SOD3 transgenic mice during hypoxic stress. Inconclusion, our current results indicate that NADPH oxidasemediatedROS generation is associated with hypoxic stress inthe mouse kidney and that SOD3 and Prdx2 cooperate toregulate cellular redox reactions during hypoxia.
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참고문헌 (23)
참고문헌 신청
Basile DP / 2003 / Chronic renal hypoxia following ischemia/reperfusion injury: effects of L-arginine on hypoxia and secondary damage / Am J Physiol Renal Physiol 284 : F338
Block ML / 2008 / NADPH oxidase as a therapeutic target in Alzheimer's disease / BMC Neurosci 9 : 1 ~ 8
Callapina M / 2005 / NO restores HIF- 1α hydroxylation during hypoxia : role of reactive oxygen species / Free Radic Biol Med 39 : 925 ~ 936
Carlsson LM / 1995 / Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia / Proc Natl Acad Sci 92 : 6264 ~ 6268
Eckardt KU / 2003 / Role of hypoxia in the pathogenesis of renal disease / Blood Purif 21 : 253 ~ 257
Block ML / 2008 / NADPH oxidase as a therapeutic target in Alzheimer's disease / BMC Neurosci 9 : 1 ~ 8
Callapina M / 2005 / NO restores HIF- 1α hydroxylation during hypoxia : role of reactive oxygen species / Free Radic Biol Med 39 : 925 ~ 936
Carlsson LM / 1995 / Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia / Proc Natl Acad Sci 92 : 6264 ~ 6268
Eckardt KU / 2003 / Role of hypoxia in the pathogenesis of renal disease / Blood Purif 21 : 253 ~ 257
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