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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 25 - 33 (9page)
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Several recent studies have reported that reactive oxygen species (ROS), superoxide anion and hydrogen peroxide (H2O2), play important roles in various cellular signaling networks. NADPH oxidase (Nox) isozymes have been shown to mediate receptor-mediated ROS generation for physiological signaling processes involved in cell growth, differentiation, apoptosis, and fibrosis. Detectable intracellular levels of ROS can be induced by the electron leakage from mitochondrial respiratory chain as well as by activation of cytochrome p450, glucose oxidase and xanthine oxidase, leading to oxidative stress. The up-regulation and the hyper-activation of NADPH oxidases (Nox) also likely contribute to oxidative stress in pathophysiologic stages. Elevation of the renal ROS level through hyperglycemia-mediated Nox activation results in the oxidative stress which induces a damage to kidney tissues, causing to diabetic nephropathy (DN). Nox inhibitors are currently being developed as the therapeutics of DN. In this review, we summarize Nox-mediated ROS generation and development of Nox inhibitors for therapeutics of DN treatment.
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참고문헌 (81)
참고문헌 신청
Ameziane-El-Hassani, R. / 2005 / Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity / J. Biol. Chem 280:30046~30054
Aoyama, T. / 2012 / Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis : GKT137831as a novel potential therapeutic agent / Hepatology 56:2316~2327
Badal, S. S. / 2014 / New insights into molecular mechanisms of diabetic kidney disease / Am. J. Kidney Dis 63:S63~S83
배윤수 / 2011 / Regulation of Reactive Oxygen Species Generation in Cell Signaling / Molecules and Cells 32(6):491~509
Banfi, B. / 2004 / NOX3, a superoxide-generating NADPH oxidase of the inner ear / J. Biol. Chem 279:46065~46072
Aoyama, T. / 2012 / Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis : GKT137831as a novel potential therapeutic agent / Hepatology 56:2316~2327
Badal, S. S. / 2014 / New insights into molecular mechanisms of diabetic kidney disease / Am. J. Kidney Dis 63:S63~S83
배윤수 / 2011 / Regulation of Reactive Oxygen Species Generation in Cell Signaling / Molecules and Cells 32(6):491~509
Banfi, B. / 2004 / NOX3, a superoxide-generating NADPH oxidase of the inner ear / J. Biol. Chem 279:46065~46072
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Upregulation of NADH/NADPH oxidase 4 by angiotensin II induces podocyte apoptosis
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Roles of Reactive Oxygen Species in Rheumatoid Arthritis Pathogenesis
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NOX4 affects the stage of neural differentiation in the hippocampus through independent with an inflammatory contribution
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ROS generation of pro-inflammatory macrophage through NADPH oxidase 2 via endocytosis of monomeric TLR4-MD2 complex
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