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학술저널
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거트앤리버 발행위원회 Gut and Liver Gut and Liver 제10권 제5호
발행연도
2016.1
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826 - 835 (10page)

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Background/Aims: Nicotinamide adenine dinucleotide phosphate oxidase (NOX)-mediated reactive oxygen species contribute to various liver diseases, including hepatocellular carcinoma (HCC). Uncertainties remain regarding the prognostic relevance of NOX1 and NOX4 protein expression in HCC. Methods: NOX1 and NOX4 protein expression was examined by using immunohistochemistry in tumor tissue from 227 HCC patients who underwent hepatectomy. Results: High immunoreactivity for NOX1 was observed in 197 (86.8%) of the 227 HCC cases and low immunoreactivity for NOX4 in 112 (49.3%). NOX1 and NOX4 proteins had opposite prognostic effects. High NOX1 expression was an independent predictor of both shorter recurrence-free survival (RFS) (p<0.01) and shorter overall survival (OS) (p=0.01). Low NOX4 expression was an independent predictor of both shorter RFS (p<0.01) and shorter OS (p=0.01). Subgroup analysis showed that, among patients with normal α-fetoprotein levels, patients with tumor size ≤5.0 cm and patients in Barcelona Clinic Liver Cancer stage A, high NOX1 expression had unfavorable effects on RFS, whereas low NOX4 expression had unfavorable effects on both RFS and OS. Conclusions: These findings demonstrated that NOX1 and NOX4 protein expression had opposite prognostic effects for HCC patients. Moreover, both proteins had prognostic value in HCC patients with normal α-fetoprotein levels or with early-stage HCC.
#Background/Aims: Nicotinamide adenine dinucleotide phosphate oxidase #NOX)-mediated reactive oxygen species contribute to various liver diseases #including hepatocellular carcinoma #HCC). Uncertainties remain regarding the prognostic relevance of NOX1 and NOX4 protein expression in HCC. Methods: NOX1 and NOX4 protein expression was examined by using immunohistochemistry in tumor tissue from 227 HCC patients who underwent hepatectomy. Results: High immunoreactivity for NOX1 was observed in 197 #86.8%) of the 227 HCC cases and low immunoreactivity for NOX4 in 112 #49.3%). NOX1 and NOX4 proteins had opposite prognostic effects. High NOX1 expression was an independent predictor of both shorter recurrence-free survival #RFS) #p& #lt #0.01) and shorter overall survival #OS) #p=0.01). Low NOX4 expression was an independent predictor of both shorter RFS #p& #lt #0.01) and shorter OS #p=0.01). Subgroup analysis showed that #among patients with normal α-fetoprotein levels #patients with tumor size ≤5.0 cm and patients in Barcelona Clinic Liver Cancer stage A #high NOX1 expression had unfavorable effects on RFS #whereas low NOX4 expression had unfavorable effects on both RFS and OS. Conclusions: These findings demonstrated that NOX1 and NOX4 protein expression had opposite prognostic effects for HCC patients. Moreover #both proteins had prognostic value in HCC patients with normal α-fetoprotein levels or with early-stage HCC.

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참고문헌 신청
Poon RT / 2011 / Prevention of recurrence after resection of hepatocellular carcinoma: a daunting challenge / Hepatology 54:757~759 google schola Llovet JM / 2005 / Resection and liver transplantation for hepatocellular carcinoma / Semin Liver Dis 25:181~200 google schola Qin LX / 2004 / Recent progress in predictive biomarkers for metastatic recurrence of human hepatocellular carcinoma: a review of the literature / J Cancer Res Clin Oncol 130:497~513 google schola Bedard K / 2007 / The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology / Physiol Rev 87:245~313 google schola Lambeth JD / 2004 / NOX enzymes and the biology of reactive oxygen / Nat Rev Immunol 4:181~189 google schola

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