지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 853 - 861 (9page)
이용수
초록· 키워드
오류제보하기
Purpose Cancer cells frequently express genes that are specifically or preferentially expressed inmale germ cells under normal conditions. The ATPase family AAA domain-containing 2(ATAD2) is one such and works as an important cofactor for MYC-dependent transcription.
In hepatocellular carcinoma (HCC), ATAD2 has been identified as a candidate driver genelocated within the amplified 8q24 locus. However, the prognostic significance of ATAD2protein expression in HCC remains uncertain.
Materials and MethodsWe investigated ATAD2 protein expression by immunohistochemistry in tumor tissue from182 HCC patients who underwent curative resection. Associations of ATAD2 expressionwith clinicopathologic variables or prognosis of HCC patients were analyzed.
ResultsATAD2 expression was observed in 119 (65.4%) of the 182 HCCs and tended to be independentpredictor of early recurrence (p=0.059). ATAD2 expression showed an unfavorableinfluence on recurrence-free survival (RFS) (p < 0.001). Subgroup analysis among patientswith tumor size ! 5.0 cm (n=109), patients at Barcelona Clinic Liver Cancer stage 0 or A(n=92), and patients with "-fetoprotein ! 20 ng/mL (n=61), the ATAD2-positive groupsunfavorably influenced RFS (p=0.008, p=0.009, and p=0.013, respectively). In addition,ATAD2 expression was an independent predictor of shorter RFS (p=0.002). ATAD2 expressionshowed an unfavorable influence on disease-specific survival (p=0.001), but was notan independent predictor of shorter disease-specific survival (p=0.109).
ConclusionATAD2 protein expression may be a potential predictor of RFS in HCC patients after curativeresection and ATAD2 may have prognostic value in patients with early stage HCC or normalserum "-fetoprotein level.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Altekruse SF / 2009 / Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005 / J Clin Oncol 27 : 1485 ~ 1491
Caron C / 2010 / Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers / Oncogene 29 : 5171 ~ 5181
Ciro M / 2009 / ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors / Cancer Res 69 : 8491 ~ 8498
Cucchetti A / 2009 / Comparison of recurrence of hepatocellular carcinoma after resection in patients with cirrhosis to its occurrence in a surveilled cirrhotic population /
Edge SB / 2010 / AJCC cancer staging manual / Springer : 191 ~ 195
Caron C / 2010 / Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers / Oncogene 29 : 5171 ~ 5181
Ciro M / 2009 / ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors / Cancer Res 69 : 8491 ~ 8498
Cucchetti A / 2009 / Comparison of recurrence of hepatocellular carcinoma after resection in patients with cirrhosis to its occurrence in a surveilled cirrhotic population /
Edge SB / 2010 / AJCC cancer staging manual / Springer : 191 ~ 195
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Expression of PEG10 Is Associated with Poor Survival and Tumor Recurrence in Hepatocellular Carcinoma
Cancer Research and Treatment
2015 .01
-
Advances in Management of Hepatocellular Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Hepatocellular carcinoma surveillance in the 21st century: Saving lives or causing harm?
Clinical and Molecular Hepatology
2019 .01
-
Substantial risk of recurrence even after 5 recurrence-free years in early-stage hepatocellular carcinoma patients
Clinical and Molecular Hepatology
2020 .01
-
Prognosis of Spontaneous Bacterial Peritonitis in Hepatocellular Carcinoma Patients
Journal of Korean Medical Science
2018 .01
-
Early disseminated recurrence after liver resection in solitary hepatocellular carcinoma
Annals of Surgical Treatment and Research
2018 .03
-
Independent Risk Factors for Hepatocellular Carcinoma Recurrence after Direct-Acting Antiviral Therapy in Patients with Chronic Hepatitis C
Gut and Liver
2021 .01
-
NADPH Oxidase 1 and NADPH Oxidase 4 Have Opposite Prognostic Effects for Patients with Hepatocellular Carcinoma after Hepatectomy
Gut and Liver
2016 .01
-
환자표본자료를 이용한 간세포암종 환자의 의료이용 특성 및 치료별 의료비용 분석
한국임상약학회지
2021 .01
-
단일 거대 간세포암의 수술적 절제 후 급격히 다발성 간외 전이가 진행된1예
Journal of Liver Cancer
2016 .01
-
Liver Transplantation in Mixed Hepatocellular Carcinoma and Cholangiocarcinoma
Journal of Liver Cancer
2019 .01
-
간세포암의 진단과 치료에서 종양표지자의 역할
대한내과학회지
2020 .02
-
Current Trends and Recent Advances in Diagnosis, Therapy, and Prevention of Hepatocellular Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Detect or not to detect very early stage hepatocellular carcinoma? The western perspective
Clinical and Molecular Hepatology
2019 .01
-
High Prevalence of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Infection in Thailand
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Comparisons between non-alcoholic steatohepatitis and alcohol-related hepatocellular carcinoma
Clinical and Molecular Hepatology
2020 .01
-
Prognosis after intrahepatic recurrence in the patients who underwent curative resection for hepatocellular carcinoma
Annals of Hepato-Biliary-Pancreatic Surgery
2020 .11
-
Treatment Outcomes and Prognostic Factors of Acute Variceal Bleeding in Patients with Hepatocellular Carcinoma
Gut and Liver
2020 .01
-
Change in the Recurrence Pattern and Predictors over Time after Complete Cure of Hepatocellular Carcinoma
Gut and Liver
2021 .01
-
Role of Surgery in Stage IV Hepatocellular Carcinoma (HCC)
대한임상종양학회 학술대회지
2015 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0