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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016
- 수록면
- 53 - 62 (10page)
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초록· 키워드
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In the present study, we evaluated the effect of CGM on osteogenic differentiation of cultured osteoblasts, and determined whether combination treatment with LLLT had synergistic effects on osteogenic differentiation.
The results indicated that CGM promoted proliferation, differentiation, and mineralization of osteoblasts at the threshold concentration of 10 μg/ml; whereas, CGM showed cytotoxic properties at concentrations above 100 μg/ml. ALP activity and mineralization were increased at concentrations above 10 μg/ml . CGM in concentrations up to 10 μg/ml also increased the expression of osteoblast-activated factors including type I collagen, BMP-2, RUNX2, and Osterix. The CGM (50 μg/ml) and LLLT (80 mW for 15 sec) combination treatment group showed the highest proliferation levels, ALP activity, and mineralization ratios. The combination treatment also increased the levels of phosphorylated forms of p38, ATF2, PKD, ERK, and JNK. In addition, the osteoblast differentiation factors including type I collagen, BMP-2, RUNX2, and Osterix protein levels were clearly increased in the combination treatment group. These results suggested that the combination treatment of CGM and LLLT has synergistic effects on the differentiation and mineralization of osteoblastic cells.
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등록된 정보가 없습니다.
참고문헌 (47)
참고문헌 신청
Ivana Stanojkovic / 2013 / Relationship between bone resorption, oxidative stress and inflammation in severe COPD exacerbation / Clinical Biochemistry 46(16-17):1678~1682
Jing Jian / 2015 / Calycosin-7-O-β-d-glucopyranoside stimulates osteoblast differentiation through regulating the BMP/WNT signaling pathways / Acta Pharmaceutica Sinica B 5(5):454~460
G. A. Rodan / 2000 / Therapeutic Approaches to Bone Diseases / Science 289(5484):1508~1514
Boufker HI / 2010 / The Src inhibitor dasatinib accelerates the differentiation of human bone marrow-derived mesenchymal stromal cells into osteoblasts / BMC cancer 10:298
Osta B / 2014 / Classical and paradoxical effects of TNF-α on bone homeostasis / Frontiers in immunology 5
Jing Jian / 2015 / Calycosin-7-O-β-d-glucopyranoside stimulates osteoblast differentiation through regulating the BMP/WNT signaling pathways / Acta Pharmaceutica Sinica B 5(5):454~460
G. A. Rodan / 2000 / Therapeutic Approaches to Bone Diseases / Science 289(5484):1508~1514
Boufker HI / 2010 / The Src inhibitor dasatinib accelerates the differentiation of human bone marrow-derived mesenchymal stromal cells into osteoblasts / BMC cancer 10:298
Osta B / 2014 / Classical and paradoxical effects of TNF-α on bone homeostasis / Frontiers in immunology 5
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