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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 13 - 30 (18page)
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초록· 키워드
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Chios gum mastic (CGM) is a resin extracted from the stem and leaves of Pistacia lentiscus L. var. chia. It has been used as a traditional medicine in many Mediterranean countries. Recently, numerous researches have demonstrated that CGM induces cell cycle arrest and apoptosis in many cancer cells. In the present study, an alteration of the cell cycle and induction of apoptosis by CGM treatment on malignant melanoma was investigated. CGM treatment showed the inhibition of cell viability in a dose- and time-dependent manner on the G631 melanoma cell line. Apoptotic hallmarks, such as nuclear condensation and DNA fragmentation, were also identified in CGM-treated cells. Several lines of apoptotic manifestation were demonstrated. The proapoptotic factor Bax was increased in a time-dependent manner, leading to MMP loss, proteasome activity reduction, AIF translocation, and cytochrome c release. Activation of caspases, such as caspase-9, -7, and -3, led to the cleavage of PARP and DFF45 (ICAD). DFF40 (CAD) was translocated into the nucleus from the cytoplasm of the CGM-treated G361 cells. CGM halted the cell cycle progression by G1 arrest and the reduction in the level of cyclin-dependent kinases (CDKs). Accumulation of p53 protein was not observed in cells treated with CGM for 24?72 h. The level of p27KIP1 was increased by CGM treatment only for an initial 24-h period. Cyclin D1, D3, and E protein levels were diminished in CGM-treated cells. Therefore, it is possible that CGM treatment could serve as a novel therapeutic strategy against human melanoma.
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참고문헌 (49)
참고문헌 신청
He ML / 2007 / Mechanisms of antiprostate cancer by gum mastic: NF-kappaB signal as target / Acta Pharmacol Sin 28:446~452
K.V. Balan / 2007 / Antiproliferative activity and induction of apoptosis in human colon cancer cells treated in vitro with constituents of a product derived from Pistacia lentiscus L. var. chia / Phytomedicine 14(4):263~272
D. S. Rigel / 2000 / Malignant melanoma: prevention, early detection, and treatment in the 21st century / CA: A Cancer Journal for Clinicians 50(4):215~236
Arata Tsutsumida / 2005 / Treatment strategy for cutaneous malignant melanoma / International Journal of Clinical Oncology 10(5):311~317
Frank O Nestle / 1999 / New perspectives on immunobiology and immunotherapy of melanoma / Immunology Today 20(1):5~7
K.V. Balan / 2007 / Antiproliferative activity and induction of apoptosis in human colon cancer cells treated in vitro with constituents of a product derived from Pistacia lentiscus L. var. chia / Phytomedicine 14(4):263~272
D. S. Rigel / 2000 / Malignant melanoma: prevention, early detection, and treatment in the 21st century / CA: A Cancer Journal for Clinicians 50(4):215~236
Arata Tsutsumida / 2005 / Treatment strategy for cutaneous malignant melanoma / International Journal of Clinical Oncology 10(5):311~317
Frank O Nestle / 1999 / New perspectives on immunobiology and immunotherapy of melanoma / Immunology Today 20(1):5~7
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