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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 105 - 111 (7page)
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β-carotene is present in carrots, pumpkins, and sweet potatoes. It suppresses many types of cancers by regulating cellular proliferation and apoptosis through a variety of mechanisms. However, the effects of β -carotene on oral cancer cells have not been clearly established. The main goal of this study was to investigate the effects of β-carotene on cell growth and apoptosis in oral cancer cells. Our results demonstrate that treatment with β-carotene induced inhibition of cell growth, and that the effect was dependent on β-carotene treatment time and concentration in KB cells.
Furthermore, treatment with β-carotene induced nuclear condensation and fragmentation in KB cells. β-carotene promoted proteolytic cleavage of procaspase-3, -7, -8 and –9 with associated increases in the concentration of cleaved caspase-3, -7, -8 and –9. In addition, the level of cleaved PARP was increased by β-carotene treatment in KB cells. These results suggest that β-carotene can suppress cell growth and induce apoptosis in KB human oral cancer cells, and that it may have potential usefulness in anti-cancer drug discovery efforts.
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참고문헌 (25)
참고문헌 신청
Armstrong GA / 1996 / Carotenoids 2: Genetics and molecular biology of carotenoid pigment biosynthesis / FASEB J 10:228~237
Kidd P / 2011 / Astaxanthin, Cell Membrane Nutrient with Diverse Clinical Benefits and Anti-Aging Potential / Alt Med Rev 16:335~364
Tomasz Sacha / 2005 / The effect of β-carotene and its derivatives on cytotoxicity, differentiation, proliferative potential and apoptosis on the three human acute leukemia cell lines: U-937, HL-60 and TF-1 / Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1740(2):206~214
Tomio Narisawa / 1996 / Inhibitory effects of natural carotenoids, α-carotene, β-carotene, lycopene and lutein, on colonic aberrant crypt foci formation in rats / Cancer Letters 107(1):137~142
Kotake-Nara E / 2001 / Carotenoids affect proliferation of human prostate cancer cells / J Nutri 131:3303~3306
Kidd P / 2011 / Astaxanthin, Cell Membrane Nutrient with Diverse Clinical Benefits and Anti-Aging Potential / Alt Med Rev 16:335~364
Tomasz Sacha / 2005 / The effect of β-carotene and its derivatives on cytotoxicity, differentiation, proliferative potential and apoptosis on the three human acute leukemia cell lines: U-937, HL-60 and TF-1 / Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1740(2):206~214
Tomio Narisawa / 1996 / Inhibitory effects of natural carotenoids, α-carotene, β-carotene, lycopene and lutein, on colonic aberrant crypt foci formation in rats / Cancer Letters 107(1):137~142
Kotake-Nara E / 2001 / Carotenoids affect proliferation of human prostate cancer cells / J Nutri 131:3303~3306
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