지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background/Aims : Statins have been a mainstay of treatment for primary and secondary prevention of coronary heart disease through their beneficial effect on lipid profile. However, their effect on the HDL cholesterol level has been determined to be equivocal or unclear. This study sought to investigate HDL cholesterol response to statin treatment in type 2 diabetic patients.
Methods : We retrospectively assessed the effect of statins in 217 patients with type 2 diabetes and dyslipidemia through chart review. Patients who were using medications such as fibrates, niacin, or thiazolidinediones, or had a plasma creatinine concentration greater than 1.5 mg/dL, a fasting triglyceride level greater than 300 mg/dL, or chronic liver disease, were excluded from the study.
Result : The mean level of LDL cholesterol was significantly decreased, and the percentage of patients who achieved the normal LDL cholesterol level was increased in this study. The mean HDL cholesterol level after statin treatment was decreased by 2.3%. The percent change of HDL cholesterol was affected by baseline HDL cholesterol level, percent change of total cholesterol, percent change of LDL cholesterol, and baseline total cholesterol level. When subjects were divided into quintiles according to baseline HDL cholesterol, HDL cholesterol level was found to be increased in the lowest two quintiles while it was decreased in the highest two quintiles.
Conclusions : There were some patients whose HDL cholesterol level was decreased after statin treatment, depending on their baseline HDL cholesterol level. We think further study on the effect of statins on HDL level will be needed in the future. (Korean J Med 74:411-417, 2008)
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참고문헌 (18)
참고문헌 신청
Austin MA / 1998 / Candidate-gene studies of the atherogenic lipoprotein phenotype: a sib-pair linkage analysis of DZ women twins / Am J Hum Genet 62 : 406 ~ 419
Bruckert E / 2007 / Low HDL- cholesterol is common in European Type 2 diabetic patients receiving treatment for dyslipidaemia: data from a pan- European survey / Diabet Med 2
Chapman MJ / 2006 / Therapeutic elevation of HDL-cholesterol to prevent atherosclerosis and coronary heart disease / Pharmacol Ther 111 : 893 ~ 908
Colhoun HM / 2004 / Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre ra
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults / 2001 / Executive Summary of The Third Report of The National Cholesterol Education
Bruckert E / 2007 / Low HDL- cholesterol is common in European Type 2 diabetic patients receiving treatment for dyslipidaemia: data from a pan- European survey / Diabet Med 2
Chapman MJ / 2006 / Therapeutic elevation of HDL-cholesterol to prevent atherosclerosis and coronary heart disease / Pharmacol Ther 111 : 893 ~ 908
Colhoun HM / 2004 / Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre ra
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults / 2001 / Executive Summary of The Third Report of The National Cholesterol Education
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