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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 297 - 305 (9page)
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초록· 키워드
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Background: High-density lipoprotein cholesterol (HDL-C) is a complex mixture of subclasses with heterogeneous atheroprotective activities. We analyzed HDL-C subclass in relation to cardiovascular risk and metabolic syndrome (MetS) in a population with high HDL-C levels. Methods: A total of 300 Korean individuals with high HDL-C levels (≥2.331 mmol/L) were enrolled following a comprehensive general medical examination including body composition analysis. HDL3-C levels were measured using the HDL3-EX SEIKEN kit (Randox Ltd., Crumlin, UK) and non-HDL3-C levels were calculated by subtracting HDL3-C levels from total HDL-C levels. Results: HDL3-C levels and HDL3-C proportion had a weak positive correlation with low-density lipoprotein cholesterol (LDL-C) and triglycerides (r=0.21, r=0.25; r=0.26, r=0.34, respectively, all P<0.001); in contrast, non-HDL3-C levels had a weak negative correlation with these parameters (r=-0.17 and r=-0.25, respectively, both P<0.005). HDL3-C levels and HDL3-C proportion were significantly higher in the MetS group (N=8) than in the non-MetS group (0.71 vs 0.63 mmol/L, P=0.001; 29.7 vs 25.8%, P=0.001, respectively); these were the only predictors of MetS among the lipid variables (areas under the curves [AUC]=0.84 and 0.83, respectively, both P=0.001). Conclusions: In populations with high HDL-C levels, HDL-C subclass may provide a greater amount of information on cardiovascular risk and MetS than HDL-C levels alone.
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참고문헌 (34)
참고문헌 신청
Wilson PW / 1988 / High density lipoprotein cholesterol and mortality. The Framingham Heart Study / Arteriosclerosis 8:737~741
Gordon DJ / 1989 / High-density lipoprotein–the clinical implications of recent studies / N Engl J Med 321:1311~1316
Voight BF / 2012 / Plasma HDL cholesterol and risk of myocardial infarction : a Mendelian randomisation study / Lancet 380:572~580
AIM-HIGH Investigators / 2011 / Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy / N Engl J Med 365:2255~2267
Madsen CM / 2017 / Extreme high-density lipoprotein cholesterol is paradoxically associated with high mortality in men and women: two prospective cohort studies / Eur Heart J 38:2478~2486
Gordon DJ / 1989 / High-density lipoprotein–the clinical implications of recent studies / N Engl J Med 321:1311~1316
Voight BF / 2012 / Plasma HDL cholesterol and risk of myocardial infarction : a Mendelian randomisation study / Lancet 380:572~580
AIM-HIGH Investigators / 2011 / Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy / N Engl J Med 365:2255~2267
Madsen CM / 2017 / Extreme high-density lipoprotein cholesterol is paradoxically associated with high mortality in men and women: two prospective cohort studies / Eur Heart J 38:2478~2486
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