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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 236 - 247 (12page)
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Background and Objectives: Recent studies have examined the structure-function relationship of high-density lipoprotein (HDL). This study aimed to identify and rank HDL-associated proteins involved in several biological function of HDL. Methods: HDLs isolated from 48 participants were analyzed. Cholesterol efflux capacity, effect of HDL on nitric oxide production, and vascular cell adhesion molecule-1 expression were assessed. The relative abundance of identified proteins in the highest vs. lowest quartile was expressed using the normalized spectral abundance factor ratio. Results: After adjustment by multiple testing, six proteins, thyroxine-binding globulin, alpha-1B-glycoprotein, plasma serine protease inhibitor, vitronectin, angiotensinogen, and serum amyloid A-4, were more abundant (relative abundance ratio ≥2) in HDLs with the highest cholesterol efflux capacity. In contrast, three proteins, complement C4-A, alpha-2-macroglobulin, and immunoglobulin mu chain C region, were less abundant (relative abundance ratio <0.5). In terms of nitric oxide production and vascular cell adhesion molecule-1 expression, no proteins showed abundance ratios ≥2 or <0.5 after adjustment. Proteins correlated with the functional parameters of HDL belonged to diverse biological categories. Conclusions: In summary, this study ranked proteins showing higher or lower abundance in HDLs with high functional capacities and newly identified multiple proteins linked to cholesterol efflux capacity.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Gordon SM / 2011 / High density lipoprotein : it's not just about lipid transport anymore / Trends Endocrinol Metab 22:9~15
Vaisar T / 2012 / Proteomics investigations of HDL : challenges and promise / Curr Vasc Pharmacol 10:410~421
Riwanto M / 2013 / Altered activation of endothelial anti-and proapoptotic pathways by high-density lipoprotein from patients with coronary artery disease : role of high-density lipoprotein-proteome remodeling / Circulation 127:891~904
Kopecky C / 2015 / Restoration of renal function does not correct impairment of uremic HDL properties / J Am Soc Nephrol 26:565~575
Darabi M / 2016 / Therapeutic applications of reconstituted HDL : when structure meets function / Pharmacol Ther 157:28~42
Vaisar T / 2012 / Proteomics investigations of HDL : challenges and promise / Curr Vasc Pharmacol 10:410~421
Riwanto M / 2013 / Altered activation of endothelial anti-and proapoptotic pathways by high-density lipoprotein from patients with coronary artery disease : role of high-density lipoprotein-proteome remodeling / Circulation 127:891~904
Kopecky C / 2015 / Restoration of renal function does not correct impairment of uremic HDL properties / J Am Soc Nephrol 26:565~575
Darabi M / 2016 / Therapeutic applications of reconstituted HDL : when structure meets function / Pharmacol Ther 157:28~42
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