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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 252 - 257 (6page)
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Objectives The aim of this study was to examine the associations of cholesterol ester transfer protein (CETP) rs6499861 and rs12708980 with high-density lipoprotein cholesterol (HDL-C) considering obesity and family history of diabetes (FHD) in Korean men and women. Methods We analyzed the association of CETP single nucleotide polymorphisms (SNPs) with HDL-C among individuals selected from a hospital (n=4 294) and the Bundang-gu area in Korea (n=2 304). Results We found that the CETP SNP rs6499861 was associated with a lower HDL-C level (effect per allele: −2.044 mg/dL, p<0.0001). Individuals with a rs6499861 CG/GG genotype had a 1.45-fold higher risk of an abnormal level of HDL-C (<40 mg/dL) than those with a CC genotype. This genotype-HDL-C association was stronger in women (odds ratio [OR], 1.99; 95% confidence interval [CI], 1.39–2.85) compared with men (OR, 1.33; 95% CI, 1.10–1.61) and in women with a FHD (OR, 4.82; 95% CI, 1.86–12.5; p=0.0012) compared with women without a family history. Relative to individuals with a CC genotype and body mass index (BMI) <25.69 kg/m2, individuals with a CG/GG genotype and BMI ≥25.69 kg/m2 had an OR (95% CI) of 2.61 (1.97–3.47). Conclusions These findings indicate that CETP variants are linked to HDL-C level in Koreans and that this link is stronger in obese men and in women who have a FHD.
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참고문헌 (23)
참고문헌 신청
Assmann G / 2004 / HDL cholesterol and protective factors in atherosclerosis / Circulation 109(Suppl 1):III8~III14
Sy RG / 2007 / Human cholestryl ester transfer protein (TaqIB) polymorphism among Filipinos with cardiovascular risk factors / J Atheroscler Thromb 14:116~121
Teramoto T / 2008 / Practical risk prediction tools for coronary heart disease in mild to moderate hypercholesterolemia in Japan: originated from the MEGA study data / Circ J 72:1569~1575
Hou H / 2017 / Association between six CETP polymorphisms and metabolic syndrome in Uyghur adults from Xinjiang, China / Int J Environ Res Public Health 14:E653
Agirbasli M / 2013 / Multi-locus candidate gene analyses of lipid levels in a pediatric Turkish cohort: lessons learned on LPL , CETP , LIPC , ABCA1 , and SHBG 17:636~645
Sy RG / 2007 / Human cholestryl ester transfer protein (TaqIB) polymorphism among Filipinos with cardiovascular risk factors / J Atheroscler Thromb 14:116~121
Teramoto T / 2008 / Practical risk prediction tools for coronary heart disease in mild to moderate hypercholesterolemia in Japan: originated from the MEGA study data / Circ J 72:1569~1575
Hou H / 2017 / Association between six CETP polymorphisms and metabolic syndrome in Uyghur adults from Xinjiang, China / Int J Environ Res Public Health 14:E653
Agirbasli M / 2013 / Multi-locus candidate gene analyses of lipid levels in a pediatric Turkish cohort: lessons learned on LPL , CETP , LIPC , ABCA1 , and SHBG 17:636~645
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