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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 223 - 229 (7page)
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초록· 키워드
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Epidemiological data clearly show the existence of a strong inverse correlation between plasma high-density lipoprotein cholesterol(HDL-C) concentrations and the incidence of coronary heart disease. This relation is explained by a number of atheroprotectiveproperties of HDL, first of all the ability to promote macrophage cholesterol transport. HDL are highly heterogeneous andare continuously remodeled in plasma thanks to the action of a number of proteins and enzymes. Among them, lecithin:cholesterolacyltransferase (LCAT) plays a crucial role, being the only enzyme able to esterify cholesterol within lipoproteins. LCAT is synthetizedby the liver and it has been thought to play a major role in reverse cholesterol transport and in atheroprotection. However,data from animal studies, as well as human studies, have shown contradictory results. Increased LCAT concentrations are associatedwith increased HDL-C levels but not necessarily with atheroprotection. On the other side, decreased LCAT concentrationand activity are associated with decreased HDL-C levels but not with increased atherosclerosis. These contradictory resultsconfirm that HDL-C levels per se do not represent the functionality of the HDL system.
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등록된 정보가 없습니다.
참고문헌 (52)
참고문헌 신청
Gordon T / 1977 / High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study / Am J Med 62:707~714
Assmann G / 1996 / Highdensity lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport / Atherosclerosis 124(Suppl):S11~S20
Barter PJ / 2007 / Effects of torcetrapib in patients at high risk for coronary events / N Engl J Med 357:2109~2122
Schwartz GG / 2012 / Effects of dalcetrapib in patients with a recent acute coronary syndrome / N Engl J Med 367:2089~2099
AIM-HIGH Investigators / 2011 / Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy / N Engl J Med 365:2255~2267
Assmann G / 1996 / Highdensity lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport / Atherosclerosis 124(Suppl):S11~S20
Barter PJ / 2007 / Effects of torcetrapib in patients at high risk for coronary events / N Engl J Med 357:2109~2122
Schwartz GG / 2012 / Effects of dalcetrapib in patients with a recent acute coronary syndrome / N Engl J Med 367:2089~2099
AIM-HIGH Investigators / 2011 / Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy / N Engl J Med 365:2255~2267
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