개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The postmortem diagnosis of ischemic heart disease is sometimes difficult for forensicpathologists especially when microscopic ischemic change in the myocardium is notdetected at the early stages of ischemic injury by conventional staining techniques.
Connexin 43 (Cx43) is a gap junction protein in human myocardium, which is phosphorylatedand localized to the intercalated discs in the normal cardiac muscles.
However, during ischemia and hypoxia, total Cx43 (tCx43) undergoes progressivedephosphorylation and concomitant accumulation of non-phosphorylated Cx43(npCx43) at the lateral cell borders. This study was aimed to evaluate the efficacy ofthe immunohistochemical expression of Cx43 in the myocardium as an early ischemicmarker in forensic autopsy. The study group consisted of 24 cases listing patients whodied of ischemic heart disease (IHD) with severe coronary atherosclerosis thatshowed no myocardial pathology. Cases of sudden death of individuals from non-IHD(n=16) were used as controls. The survival times in both IHD and non-IHD groupswere within 24 hours of the onset of angina symptoms, related injury, or the event forthe cause of death. There was a statistically significant difference in tCx43 andnpCX43 immunopositivity in the IHD group due to their expression patterns. In theIHD group, the redistribution of Cx43 expression from the intercalated discs to the lateralcell borders occurred more frequently than in the non-IHD group. In conclusion,the different expression patterns of tCx43 and npCx43 in the myocardium in IHDcould be used as adjunctive ischemic markers.
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Beardslee MA / 2000 / Dephosphorylation and intracellular redistribution of ventricular connexin43during electrical uncoupling induced by ischemia / Circ Res 87 : 656 ~ 662
Campobasso CP / 2008 / Sudden cardiac death and myocardial ischemia indicators: a comparative study of four immunohistochemical markers / Am J Forensic Med Pathol 29 : 154 ~
Hatanaka K / 2004 / Down-regulation of connexin43 in early myocardial ischemia and protective effect by ischemic preconditioning in rat hearts in vivo / Jpn Heart J 45 : 1007
Kawamoto O / 2014 / Immunohistochemistry of connexin43 and zonula occludens-1 in the myocardium as markers of early ischemia in autopsy material / Histol Histopathol 29 : 76
Laird DW. / 2006 / Life cycle of connexins in health and disease / Biochem J 394 : 527 ~ 543
Campobasso CP / 2008 / Sudden cardiac death and myocardial ischemia indicators: a comparative study of four immunohistochemical markers / Am J Forensic Med Pathol 29 : 154 ~
Hatanaka K / 2004 / Down-regulation of connexin43 in early myocardial ischemia and protective effect by ischemic preconditioning in rat hearts in vivo / Jpn Heart J 45 : 1007
Kawamoto O / 2014 / Immunohistochemistry of connexin43 and zonula occludens-1 in the myocardium as markers of early ischemia in autopsy material / Histol Histopathol 29 : 76
Laird DW. / 2006 / Life cycle of connexins in health and disease / Biochem J 394 : 527 ~ 543
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Expression of Connexin 43 in the Myocardium in Sudden Unexplained Nocturnal Death Syndrome
대한법의학회지
2016 .01
-
Two-Sample Mendelian Randomization Study of Lipid levels and Ischemic Heart Disease
Korean Circulation Journal
2020 .01
-
Women and Ischemic Heart Disease: Recognition, Diagnosis and Management
Korean Circulation Journal
2016 .01
-
Tissue-specific Role of CX₃CR1 Expressing Immune Cells and Their Relationships with Human Disease
Immune Network
2018 .02
-
Thirty-Year Trends in Mortality from Cardiovascular Diseases in Korea
Korean Circulation Journal
2015 .01
-
Associated Factors of Ischemic Heart Disease Identified Among Post-Menopausal Women
Osong Public Health and Research Persptectives
2019 .01
-
Type 2 Diabetes Induces Prolonged P-wave Duration without Left Atrial Enlargement
Journal of Korean Medical Science
2016 .01
-
Profile of Forensic Autopsy Practices in Small Towns and Cities in Rural Areas
대한법의학회지
2015 .01
-
Cathepsin S contributes to microglia-mediated olfactory dysfunction through the regulation of Cx3cl1-Cx3cr1 axis in a Niemann-Pick disease type C1 model
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Incidence and Risk Factors for Atrial Fibrillation in Korea: the National Health Insurance Service Database (2002–2010)
Korean Circulation Journal
2016 .01
-
2016년도 법의부검에 대한 통계적 고찰
대한법의학회지
2018 .01
-
A Statistical Analysis on Forensic Autopsies Performed in Korea in 2015
대한법의학회지
2016 .01
-
Job Stress-attributable Burden of Disease in Korea
Journal of Korean Medical Science
2018 .01
-
Erratum : Laboratory Aspects of Donor Screening for Fecal Microbiota Transplantation at a Korean Fecal Microbiota Bank
Annals of Laboratory Medicine
2021 .11
-
The Association of Overt and Subclinical Hyperthyroidism with the Risk of Cardiovascular Events and Cardiovascular Mortality: Meta-Analysis and Systematic Review of Cohort Studies
Endocrinology and Metabolism
2020 .01
-
심뇌혈관질환과 우울증의 관련성 및 우울증의 영향 요인: 2014년, 2016년 국민건강영양조사
기본간호학회지
2020 .11
-
Genistein Improves the Major Depression through Suppressing the Expression of miR-221/222 by Targeting Connexin 43
PSYCHIATRY INVESTIGATION
2018 .01
-
Statin and the Risk of Ischemic Stroke or Transient Ischemic Attack in Head and Neck Cancer Patients with Radiotherapy
대한뇌졸중학회지
2018 .01
-
Cardiac Amyloidosis in Autopsy Case of Sudden Unexpected Death
대한법의학회지
2023 .02
-
Optimal Treatment of Ischemic Colitis
대한외과학회 학술대회 초록집
2022 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0