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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.2
- 수록면
- 14 - 32 (19page)
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Chemokine (C-X₃-C motif ) ligand 1 (CX₃CL1, also known as fractalkine) and its receptor chemokine (C-X₃-C motif ) receptor 1 (CX₃CR1) are widely expressed in immune cells and non-immune cells throughout organisms. However, their expression is mostly cell typespecific in each tissue. CX₃CR1 expression can be found in monocytes, macrophages, dendritic cells, T cells, and natural killer (NK) cells. Interaction between CX₃CL1 and CX₃CR1 can mediate chemotaxis of immune cells according to concentration gradient of ligands. CX₃CR1 expressing immune cells have a main role in either pro-inflammatory or anti-inflammatory response depending on environmental condition. In a given tissue such as bone marrow, brain, lung, liver, gut, and cancer, CX₃CR1 expressing cells can maintain tissue homeostasis. Under pathologic conditions, however, CX₃CR1 expressing cells can play a critical role in disease pathogenesis. Here, we discuss recent progresses of CX₃CL1/CX₃CR1 in major tissues and their relationships with human diseases.
목차
ABSTRACT
CHEMOKINE (C-X3-C MOTIF) LIGAND 1 (CX₃CL1) ANDCHEMOKINE (C-X3-C MOTIF) RECEPTOR 1 (CX₃CR1)
BONE MARROW AND IMMUNE SYSTEM
BLOOD VESSEL SYSTEM AND ATHEROSCLEROSIS
BRAIN AND NEURODEGENERATIVE DISEASES
LUNG AND ASTHMA
LIVER
GUT AND IMMUNE TOLERANCE
CANCER
CONCLUSION
REFERENCES
참고문헌 (105)
참고문헌 신청
Kim KW / 2011 / In vivo structure/function and expression analysis of the CX3C chemokine fractalkine / Blood 118:e156~e167
Imai T / 1997 / Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion / Cell 91:521~530
Hundhausen C / 2003 / The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion / Blood 102:1186~1195
Garton KJ / 2001 / Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1) / J Biol Chem 276:37993~38001
Geissmann F / 2003 / Blood monocytes consist of two principal subsets with distinct migratory properties / Immunity 19:71~82
Imai T / 1997 / Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion / Cell 91:521~530
Hundhausen C / 2003 / The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion / Blood 102:1186~1195
Garton KJ / 2001 / Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1) / J Biol Chem 276:37993~38001
Geissmann F / 2003 / Blood monocytes consist of two principal subsets with distinct migratory properties / Immunity 19:71~82
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UCI(KEPA) : I410-ECN-0101-2018-517-001801135