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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제37권 제5호
- 발행연도
- 2003.1
- 수록면
- 307 - 315 (9page)
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초록· 키워드
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Background : It is well documented that calcium ions perform a major role in neuronal degeneration in cerebrovascular disease and the other degenerative diseases, and that 1,25-dihydroxyvitamin D3 (D3) has the dose-dependent protective effects. This study was performed
to examine the effects of different D3 dosages against delayed neuronal damage of the hippocampus. Methods : Mature mongolian gerbils were injected with either 0.8 μg/kg/day (group 2) for 5 days or 1.0 μg/kg/day for 8 days (group 3) prior to the 10 min ligation of the
bilateral common carotid arteries. Immunohistochemical expression for the glial cell linederived neurotrophic factor (GDNF), the basic fibroblast growth factor (bFGF) and the plateletderived
neurotrophic factor (PDNF) was observed in the D3-injected (0.8 μ
g/kg/day for 5 days) group. Results : Group 2 showed a highly significant attenuation of delayed neuronal damage in the lateral CA1 region at 7 days after reperfusion. Group 3 showed unilateral or bilateral hemispheric infarcts 24 h after the onset of reperfusion. The D3-injected group showed a markedly increased bFGF expression level. Conclusion : The dose-dependent
effect of D3 suggests the importance of determining the appropriate D3 dose for clinical
applications. Although the mechanism(s) of neuroprotection by D3 remains unclear, D3 may facilitate a reduction in ischemia-induced oxidative stress via the activation of the neurotrophic factors, including bFGF and GDNF.
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