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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제39권 제2호
- 발행연도
- 2005.1
- 수록면
- 81 - 90 (10page)
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초록· 키워드
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Background : Glucocorticoids (GCs) are essential for normal development and the maturation of the central nervous system. The aim of this study was to determine the effects of antenatal dexamethasone (DEXA) treatment on neuronal morphogenesis and on the glial cell line-derived neurotrophic factor (GDNF) protein expression in neonatal rat. Methods : Pregnant Sprague-Dawley rats were injected with saline (the control), or 0.2 mg/kg/day DEXA or 0.8 mg/kg/day DEXA at 17th, 18th and 19th day of gestation. The newborn rat brains were examined at postnatal days 1 (n=75) and 10 (n=78). Results : The DEXA-treated groups showed distorted architectures of neurons in the cerebral cortex, hippocampus and cerebellar cortex at postnatal days 1 and 10 with an increased number of proliferating cell nuclear antigen (PCNA)-positive cells. The cerebellar cortex in the DEXA-treated groups showed delayed development with more PCNA-positive cells in the internal granular cell layer. The Purkinje cells showed a markedly decreased number and the decreased length of the dendritic processes. The GDNF positive reaction was decreased in the DEXA-treated groups in a dose-dependent manner. Conclusions : The developmental changes and neuronal degeneration at postnatal days 1 and 10 in the newborn rats that were exposed to DEXA at the late gestational age were associated with increased proliferative activity and a decreased level of GDNF protein expression.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
/ / Brain damage induced by prenatalexposure to dexamethasome in fetal rhesus macaques : 157 ~ 67
/ 1984 / The neonatal cerebellum:the highest levelof glucocorticoid receptors in the brain 314 : 13 ~ 20
/ 1990 / Exposure to excess glucocorticoidsalters dendritic morphology of adult hippocampal pyramidalneurons 531 : 225 ~ 31
/ 1990 / NT-3,BDNF,andNGF in the developing rat nervous system:parallel as well as reciprocalpatterns of expression 5 : 501 ~ 9
/ 1992 / Fetal dexamethasone exposurealters macromolecular characteristics of rat brain development:Acritical period for regionally selective alterations 46 : 45 ~ 59
/ 1984 / The neonatal cerebellum:the highest levelof glucocorticoid receptors in the brain 314 : 13 ~ 20
/ 1990 / Exposure to excess glucocorticoidsalters dendritic morphology of adult hippocampal pyramidalneurons 531 : 225 ~ 31
/ 1990 / NT-3,BDNF,andNGF in the developing rat nervous system:parallel as well as reciprocalpatterns of expression 5 : 501 ~ 9
/ 1992 / Fetal dexamethasone exposurealters macromolecular characteristics of rat brain development:Acritical period for regionally selective alterations 46 : 45 ~ 59
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