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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제51권 제1호
- 발행연도
- 2017.1
- 수록면
- 17 - 23 (7page)
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Background: Cancer stem cells have been investigated as new targets for colorectal cancer (CRC) treatment. We recently reported that CD133+ colon cancer cells showed chemoresistance to 5-fluorouracil through increased survivin expression and proposed the survivin inhibitor YM155 as an effective therapy for colon cancer in an in vitro study. Here, we investigate the relationship between survivin and CD133 expression in surgically resected CRC to identify whether the results obtained in our in vitro study are applicable to clinical samples. Methods: We performed immunohistochemical staining for survivin and CD133 in surgically resected tissue from 187 stage II or III CRC patients. We also comparatively analyzed apoptosis according to survivin and CD133 expression using terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling. Results: The results of the Mantel-Haenszel test established a linear association between nuclear survivin and CD133 expression (p = .018), although neither had prognostic significance, according to immunohistochemical expression level. No correlation was found between survivin expression and the following pathological parameters: invasion depth, lymph node metastasis, or histologic differentiation (p > .05). The mean apoptotic index in survivin+ and CD133+ tumors was higher than that in negative tumors: 5.116 ± 4.894 in survivin+ versus 4.103 ± 3.691 in survivin– (p = .044); 5.165 ± 4.961 in CD133+ versus 4.231 ± 3.812 in CD133– (p = .034). Conclusions: As observed in our in vitro study, survivin expression is significantly related to CD133 expression. Survivin may be considered as a new therapeutic target for chemoresistant CRC.
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참고문헌 (24)
참고문헌 신청
Alcaide J / 2013 / The role and prognostic value of apoptosis in colorectal carcinoma / BMC Clin Pathol 13 : 24 ~
Corbo C / 2012 / Protein cross-talk in CD133+ colon cancer cells indicates activation of the Wnt pathway and upregulation of SRp20 that is potentially involved in tumorigenic
Dalerba P / 2007 / Phenotypic characterization of human colorectal cancer stem cells / Proc Natl Acad Sci U S A 104 : 10158 ~ 10163
De Oliveira Lima F / 2009 / Immunoexpression of inhibitors of apoptosis proteins and their antagonist SMAC/DIABLO in colorectal carcinoma: correlation with apoptotic index,
Deng YH / 2010 / -Fluorouracil upregulates the activity of Wnt signaling pathway in CD133-positive colon cancer stem-like cells / Chin J Cancer 29 : 810 ~ 815
Corbo C / 2012 / Protein cross-talk in CD133+ colon cancer cells indicates activation of the Wnt pathway and upregulation of SRp20 that is potentially involved in tumorigenic
Dalerba P / 2007 / Phenotypic characterization of human colorectal cancer stem cells / Proc Natl Acad Sci U S A 104 : 10158 ~ 10163
De Oliveira Lima F / 2009 / Immunoexpression of inhibitors of apoptosis proteins and their antagonist SMAC/DIABLO in colorectal carcinoma: correlation with apoptotic index,
Deng YH / 2010 / -Fluorouracil upregulates the activity of Wnt signaling pathway in CD133-positive colon cancer stem-like cells / Chin J Cancer 29 : 810 ~ 815
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