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학술저널
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대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제18권 제3호
발행연도
2008.1
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253 - 259 (7page)

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Purpose:Zinc is a dietary antioxidant which is crucial for normal development and function of the immune system. Zinc supplementation is reported to reduce respiratory infections and prevent severe pneumonia in children. We examined serum zinc levels in young children who had recurrent wheezing and evaluated the clinical and laboratory findings in relation to serum zinc levels. Methods:Seventy three patients admitted due to lower respiratory infections with wheezing were enrolled. All children had experienced more than 3 episodes of wheezing before admission. Serum zinc levels were measured by using inductively coupled plasma-optical emission spectrometry (ICP-OES), and serum zinc level of ＜64 µg/dL was defined as zinc deficiency. Clinical and laboratory findings were evaluated and compared between the patients with zinc deficiency and those without it. Two age-matched control groups: normal controls (control 1) and patients with acute viral illnesses (control 2) were also studied. Results:Zinc levels were significantly lower in the patient group than in the 2 control groups.(P<0.0001) Zinc deficiency was observed in 49.3% of the patient group, which was significantly higher than in controls.(P<0.0001) Peripheral blood CD4/CD8 was significantly lower in the patients with zinc deficiency than in the subjects with a normal value.(P=0.01) Conclusion:This study showed that the serum zinc level was significantly lower and that zinc deficiency was more frequently observed in the patients with recurrent early wheeze. Zinc deficiency was found to be associated with lower CD4/CD8. Our results suggest that zinc deficiency may be associated with frequent respiratory infections, a likely trigger for recurrent early wheeze.
#Zinc #Recurrent wheezing

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참고문헌 (28)

참고문헌 신청
Aggarwal BB / 2004 / Nuclear transcription factor NF kappa B : role in biology and medicine / Indian J Exp Biol 42:341~353 google schola Ho LH / 2004 / Labile zinc and zinc transporter ZnT4 in mast cell granules: role in regulation of caspase activation and NF-κB translocatoin / J immunol 172:7750~7760 google schola Allen JI / 1983 / Alterations in human natural killer cell activity and monocyte cytotoxicity induced by zinc deficiency / J Lab Clin Med 102 : 577 ~ 589 google schola Baqui AH / 2003 / Simultaneous weekly supplementation of iron and zinc is associated with lower morbidity due to diarrhea and acute lower respiratory infection in Bangladesh google schola Beck FW / 1997 / Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans / Am J Physiol 272 : E1002 ~ E1007 google schola

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