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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 23 - 28 (6page)
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초록· 키워드
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Background and Purpose: Environmental factors might influence the pathogenesis of Parkinson’s disease (PD) or multiple-system atrophy (MSA), and previous examinations of pesticide exposure, well-water drinking, and farming have produced inconclusive results. Because agriculture has been of considerable importance to Korean society, and hence the risk of exposure to pesticides was high in Korea, this study investigated whether such exposure is associated with elevated risks of developing PD and MSA.
Methods: Two hundred and thirty-five PD patients, 133 MSA patients, and 77 normal control subjects were examined. Data concerning environmental factors were collected by face-to-face interviews using a structured questionnaire. Odds ratios (ORs) were calculated by binary logistic regression.
Results: ORs for environmental risk factors for developing PD were 1.06 [95% confidence interval (CI) = 1.02- 1.10] for age and 2.37 (95% CI = 1.32-4.27) for rural well-water drinking for >10 years. Smoking >10 pack-years (OR = 0.31; 95% CI = 0.11-0.64) was a preventable factor for developing PD in this study. However, no significant risk factors were identified for MSA.
Conclusions: These results suggest that exposure to certain environmental risk factors plays a role in the development of PD. However, the development of MSA appears to be independent of environmental risk factors in Korean patients.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Brown TP / 2006 / Pesticides and Parkinson’s disease??is there a link / Environ Health Perspect 114 : 156 ~ 164
Chan DK / 1998 / Genetic and environmental risk factors for Parkinson’s disease in a Chinese population / J Neurol Neurosurg Psychiatry 65 : 781 ~ 784
De Michele G / 1996 / Environmental and genetic risk factors in Parkinson’s disease: a case-control study in southern Italy / Mov Disord 11 : 17 ~ 23
Firestone JA / 2005 / Checkoway H. Pesticides and risk of Parkinson disease: a population-based case-control study / Arch Neurol 62 : 91 ~ 95
Galanaud JP / 2005 / Cigarette smoking and Parkinson’s disease: a case-control study in a population characterized by a high prevalence of pesticide expos
Chan DK / 1998 / Genetic and environmental risk factors for Parkinson’s disease in a Chinese population / J Neurol Neurosurg Psychiatry 65 : 781 ~ 784
De Michele G / 1996 / Environmental and genetic risk factors in Parkinson’s disease: a case-control study in southern Italy / Mov Disord 11 : 17 ~ 23
Firestone JA / 2005 / Checkoway H. Pesticides and risk of Parkinson disease: a population-based case-control study / Arch Neurol 62 : 91 ~ 95
Galanaud JP / 2005 / Cigarette smoking and Parkinson’s disease: a case-control study in a population characterized by a high prevalence of pesticide expos
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