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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 9 (9page)
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Cerebral ischemia is caused by arterial occlusion due to a thrombus or an embolus. Such occlusion induces multiple and concomitant pathophysiological processes that involve bioenergetic failure, acidosis, loss of cell homeostasis, excitotoxicity, and disruption of the blood-brain barrier. All of these mechanisms contribute to neuronal death, mainly via apoptosis or necrosis. The immune system is involved in this process in the early phases after brain injury, which contributes to potential enlargement of the infarct size and involves the penumbra area. Whereas inflammation and the immune system both exert deleterious effects, they also contribute to brain protection by stimulating a preconditioning status and to the concomitant repair of the injured parenchyma. This review describes the main phases of the inflammatory process occurring after arterial cerebral occlusion, with an emphasis on the role of single mediators.
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참고문헌 (24)
참고문헌 신청
Becatti M / 2014 / Oxidative modification of fibrinogen is associated with altered function and structure in the subacute phase of myocardial infarction / Arterioscler Throm
Famakin BM / 2014 / The immune response to acute focal cerebral ischemia and associated post-stroke immunodepression: a focused review / Aging Dis 5 : 307 ~ 326
Hertz L / 2008 / Bioenergetics of cerebral ischemia: a cellular perspective / Neuropharmacology 55 : 289 ~ 309
Kahlert S / 2005 / Glutamate-mediated influx of extracellular Ca2+ is coupled with reactive oxygen species generation in cultured hippocampal neurons but not in astrocytes /
Kaplan JH / 2002 / Biochemistry of Na,K-ATPase / Annu Rev Biochem 71 : 511 ~ 535
Famakin BM / 2014 / The immune response to acute focal cerebral ischemia and associated post-stroke immunodepression: a focused review / Aging Dis 5 : 307 ~ 326
Hertz L / 2008 / Bioenergetics of cerebral ischemia: a cellular perspective / Neuropharmacology 55 : 289 ~ 309
Kahlert S / 2005 / Glutamate-mediated influx of extracellular Ca2+ is coupled with reactive oxygen species generation in cultured hippocampal neurons but not in astrocytes /
Kaplan JH / 2002 / Biochemistry of Na,K-ATPase / Annu Rev Biochem 71 : 511 ~ 535
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