지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 366 - 370 (5page)
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초록· 키워드
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Background and Purpose The objective of this study was to find a sensitive method for the early detection of diabetic polyneuropathy (DPN) and determine the relationship between the functions of somatic and autonomic small nerve fibers in DPN. Methods Patients with type 2 diabetes mellitus and DPN based on clinical symptoms, signs, intraepidermal nerve fiber density (IENFD), and findings in the quantitative sudomotor axon reflex test (QSART) were enrolled retrospectively. Neurological examinations and nerve conduction studies were performed on all patients. Heart-rate variability during deep breathing (DB ratio) and the Valsalva maneuver (Valsalva ratio) were used to quantify the cardiovagal function. Patients were divided into two groups: 1) normal nerve conduction, defined as smallfiber neuropathy (SFN) and 2) abnormal nerve conduction, defined as mixed-fiber neuropathy. Results In total, 82 patients were enrolled (age: 60.7±10.7 years, mean±SD). A decreased IENFD was the most frequent abnormality across all of the patients, followed by abnormalities of the QSART and cardiovagal function. A decreased IENFD was more sensitive than the QSART, DB ratio, and Valsalva ratio for detecting diabetic SFN. The DB ratio was significantly correlated with the duration of diabetes mellitus and clinical symptoms and signs. There was no correlation between the IENFD and the findings of the QSART for the distal leg. Conclusions Measuring the IENFD was a more sensitive method than the QSART for the early detection of DPN. The degree of involvement of the somatic small nerve fibers and sudomotor nerve fibers was independent in DPN.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Adler AI / 1999 / Lower-extremity amputation in diabetes. The independent effects of peripheral vascular disease, sensory neuropathy, and foot ulcers / Diabetes Care 22 : 102
Devigili G / 2008 / The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology / Brain 131 : 1912 ~ 1925
Dyck PJ / 1988 / Detection, characterization, and staging of polyneuropathy:assessed in diabetics / Muscle Nerve 11 : 21 ~ 32
Dyck PJ / 1995 / Variables influencing neuropathic endpoints: the Rochester Diabetic Neuropathy Study of Healthy Subjects / Neurology 45 : 1115 ~ 1121
England JD / 2005 / Distal symmetric polyneuropathy: a definition for clinical research: report of the American Academy of Neurology, the American Association of Electrodiag
Devigili G / 2008 / The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology / Brain 131 : 1912 ~ 1925
Dyck PJ / 1988 / Detection, characterization, and staging of polyneuropathy:assessed in diabetics / Muscle Nerve 11 : 21 ~ 32
Dyck PJ / 1995 / Variables influencing neuropathic endpoints: the Rochester Diabetic Neuropathy Study of Healthy Subjects / Neurology 45 : 1115 ~ 1121
England JD / 2005 / Distal symmetric polyneuropathy: a definition for clinical research: report of the American Academy of Neurology, the American Association of Electrodiag
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