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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 341 - 348 (8page)
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초록· 키워드
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ObjectiveaaThis study compares the efficacy of the cholinesterase inhibitor (ChEI) galantamine on cognition in patients with mild-to-moderate Alzheimer’s dementia (AD) who were either naïve to ChEI drugs or who had failed a trial of the ChEI donepezil.
MethodsaaOutpatients with AD were sequentially referred for screening and enrollment. Current outpatients who had taken donepezil for at least 6 months without demonstrated efficacy on cognition were switched to galantamine (switched group). New outpatients with no ChEI prescription history were classified as the naïve group and were given galantamine. The primary outcome measures for the betweengroup comparison were response rate on cognition at 26 and 52 weeks (categorical) and change on the Korean version of the Alzheimer’s Disease Assessment Scale-cognitive subscale (dimensional). Secondary cognitive outcomes were measured using the subset of frontal executive function and the Korean Mini-Mental State Examination.
ResultsaaSeventy outpatients were enrolled and 66 were analyzed by Intent-to-treat (ITT). There were 42 cases in the naïve group and 24 in the switched group. Response rates did not differ at 26 weeks (71.4% naïve vs. 58.3% switched; p=0.277) or at 52 weeks (59.5% naïve vs.
41.6% switched; p=0.162). No significant differences were observed in the pattern of change over the 52 weeks on the primary and secondary cognitive scales.
ConclusionaaAs the efficacy of galantamine on cognition was not inferior in the switched group compared to that in the naïve group, switching ChEI drugs is clinically feasible for non-responding patients with mild-to-moderate AD.
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참고문헌 (39)
참고문헌 신청
Scarpini E / 2003 / Treatment of Alzheimer’s disease : current status and new perspectives / Lancet Neurol 2:539~547
Burns A / 2006 / Clinical practice with anti-dementia drugs : a consensus statement from British Association for Psychopharmacology / J Psychopharmacol 20:732~755
Wilkinson DG / 2004 / Cholinesterase inhibitors used in the treatment of Alzheimer’s disease : the relationship between pharmacological effects and clinical efficacy / Drugs Aging 21:453~478
Ritchie CW / 2004 / Metaanalysis of randomized trials of the efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer disease / Am J Geriatr Psychiatry 12:358~369
Auriacombe S / 2002 / Efficacy and safety of rivastigmine in patients with Alzheimer’s disease who failed to benefit from treatment with donepezil / Curr Med Res Opin 18:129~138
Burns A / 2006 / Clinical practice with anti-dementia drugs : a consensus statement from British Association for Psychopharmacology / J Psychopharmacol 20:732~755
Wilkinson DG / 2004 / Cholinesterase inhibitors used in the treatment of Alzheimer’s disease : the relationship between pharmacological effects and clinical efficacy / Drugs Aging 21:453~478
Ritchie CW / 2004 / Metaanalysis of randomized trials of the efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer disease / Am J Geriatr Psychiatry 12:358~369
Auriacombe S / 2002 / Efficacy and safety of rivastigmine in patients with Alzheimer’s disease who failed to benefit from treatment with donepezil / Curr Med Res Opin 18:129~138
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