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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives：Diffuse tensor imaging (DTI) was applied to explore the difference in regional distribution and extent of white
matter (WM) abnormalities in boys with Attention-deficit/hyperactivity disorder (ADHD) versus boys with comorbid ADHD
and tic disorders.
Methods：Fifteen boys with ADHD (mean age 9.3±1.8), 24 ADHD boys with chronic tic disorder or Tourette’s disorder
(9.9±1.2) and 9 age-, gender-matched controls (9.2±1.8) received DTI assessments. Fractional Anisotropy (FA) maps of WM
were compared between groups with a voxel-wise analysis after intersubject registration to MNI space.
Results：Both groups, ADHD group and ADHD with tic disorder group, commonly showed decreased FA than healthy control
group in left cerebellar middle peduncle and right frontal lobe, increased FA in right middle occipital WM. In the common areas of
left cerebellar middle peduncle and right middle occipital WM, comorbid group showed broader areas of significant FA. The
comorbid group also showed increased FA in right cerebellar peduncle, additionally.
Conclusion：The findings in ADHD group support previous ADHD hypothesis of the functional abnormalities in corticocerebellar
circuit, and suggest that ADHD might have more complicated pathology of neuronal circuit including occipital visual
system. The comorbid group showed common areas of overlapping but more extensive abnormalities and also had additional WM
abnormalities. ADHD with chronic tic disorders may represent a severe form of ADHD with additional regions of abnormal
connectivity. (J Korean Neuropsychiatr Assoc 2008;47(5):493-502)
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참고문헌 (23)
참고문헌 신청
APA / 1994 / Diagnostic and Statistical Manual for Mental Disorders. 4th ed / American Psychiatric Association Press
Ashtari M / 2005 / Attention-deficit/hyperactivity disorder: a preliminary diffusion tensor imaging study / Biological psychiatry 57 : 448 ~ 455
Berquin PC / 1998 / Cerebellum in attention-deficit hyperactivity disorder: a morphometric MRI study / Neurology 50 : 1087 ~ 1093
Castellanos FX / 2002 / Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder / Jama 288 : 1740
Chung SJ / 1998 / Development of the Korean Form of Yale Global Tic Severity Scale: A Va-lidity and Reliability Study / J Korean Neuropsychiatr Assoc 37 : 10 ~
Ashtari M / 2005 / Attention-deficit/hyperactivity disorder: a preliminary diffusion tensor imaging study / Biological psychiatry 57 : 448 ~ 455
Berquin PC / 1998 / Cerebellum in attention-deficit hyperactivity disorder: a morphometric MRI study / Neurology 50 : 1087 ~ 1093
Castellanos FX / 2002 / Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder / Jama 288 : 1740
Chung SJ / 1998 / Development of the Korean Form of Yale Global Tic Severity Scale: A Va-lidity and Reliability Study / J Korean Neuropsychiatr Assoc 37 : 10 ~
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