지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 538 - 544 (7page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaChanges in serum neurosteroid levels have been reported in stress-related disorders such as anxiety and depression, but not in patients with obsessive-compulsive disorder (OCD). We thus investigated such changes in patients with OCD.
MethodsaaWe compared the serum levels of progesterone, pregnanolone, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEA-S), cortisol and testosterone in 30 patients with OCD and 30 healthy controls.
ResultsaaWhen male and female patients were evaluated together, DHEA and cortisol levels were significantly higher in patients with OCD than the control group. When the genders were evaluated separately, DHEA and cortisol levels were higher in female patients than the female controls. The increase in DHEA levels in female patients is likely an effect of the hypothalamic-pituitary-adrenal (HPA) axis. In contrast, cortisol levels in male patients were higher than the control group, while testosterone levels were lower. The increased cortisol and decreased testosterone levels in male patients likely involves the hypothalamic-pituitary-gonadal (HPG) axis.
ConclusionaaThese findings suggest that neurosteroid levels in patients with OCD should be investigated together with the HPA and HPG axes in future studies.
목차
등록된 정보가 없습니다.
참고문헌 (51)
참고문헌 신청
Brambilla F / 2005 / Plasma concentrations of anxiolytic neuroactive steroids in men with panic disorder / Psychiatry Res 135:185~190
Semeniuk T / 2001 / Neuroactive steroid levels in patients with generalized anxiety disorder / J Neuropsychiatry Clin Neurosci 13:396~398
Spivak B / 2000 / Elevated circulatory level of GABA(A)-antagonistic neurosteroids in patients with combat-related post-traumatic stres disorder / Psychol Med 30:1227~1231
Heydari B / 2002 / Low pregnenolone sulphate plasma concentrations in patients with generalized social phobia / Psychol Med 32:929~933
Kartalcı Ş / 2008 / Neurosteroids and cognitive functions in depressed women / Bull Clin Psychopharmacol 18:9~21
Semeniuk T / 2001 / Neuroactive steroid levels in patients with generalized anxiety disorder / J Neuropsychiatry Clin Neurosci 13:396~398
Spivak B / 2000 / Elevated circulatory level of GABA(A)-antagonistic neurosteroids in patients with combat-related post-traumatic stres disorder / Psychol Med 30:1227~1231
Heydari B / 2002 / Low pregnenolone sulphate plasma concentrations in patients with generalized social phobia / Psychol Med 32:929~933
Kartalcı Ş / 2008 / Neurosteroids and cognitive functions in depressed women / Bull Clin Psychopharmacol 18:9~21
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