지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background: The relationship between dehydroepiandrosterone sulfate (DHEA-S) and bone mineral density (BMD) is controversial. And findings of most studies that have investigated this relationship are restricted to postmenopausal women. In this study, we investigated the relationship between serum DHEA-S and BMD in both men and women.
Methods: This cross-sectional study evaluated a total of 294 healthy Korean participants through a medical examination program. And a subgroup of 154 participants was subjected to a longitudinal analysis. We measured BMD by dual energy X-ray absorptiometry and assayed DHEA-S by a chemiluminescent immunoassay. Results: We evaluated the association between serum DHEA-S concentration and BMD at the femur trochanter after adjusting for cofounders such as age, body mass index, lifestyle factors, serum cortisol level, serum insulin-like growth factor 1 (IGF-1) level, and sex. Through our longitudinal study, we found that the changes in BMD at the total spine, at the femur neck, and at the femur trochanter were all smaller in the ΔDHEA-S <0 group than in the ΔDHEA-S >0 group. Conclusions: We found that there was a positive correlation between serum DHEA-S and femur BMD, which suggests that controlling serum DHEA-S levels may retard age-related BMD reduction in Koreans.
목차
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참고문헌 (23)
참고문헌 신청
Bacsi K / 2007 / CYP3A7*1C polymorphism, serum dehydroepiandrosterone sulfate level, and bone mineral density in postmenopausal women / Calcif Tissue Int 80 : 154 ~ 159
Burch J / 2014 / Systematic review of the use of bone turnover markers for monitoring the response to osteoporosis treatment: the secondary prevention of fractures, and prima
Chang KP / 2004 / Incidence of hip and other osteoporotic fractures in elderly men and women: Dubbo Osteoporosis Epidemiology Study / J Bone Miner Res 19 : 532 ~ 536
Dhatariya KK / 2003 / Dehydroepiandrosterone: is there a role for replacement? / Mayo Clin Proc 78 : 1257 ~ 1273
El-Maouche D / 2015 / Cortical bone mineral density in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency / Clin Endocrinol 82 : 330 ~ 337
Burch J / 2014 / Systematic review of the use of bone turnover markers for monitoring the response to osteoporosis treatment: the secondary prevention of fractures, and prima
Chang KP / 2004 / Incidence of hip and other osteoporotic fractures in elderly men and women: Dubbo Osteoporosis Epidemiology Study / J Bone Miner Res 19 : 532 ~ 536
Dhatariya KK / 2003 / Dehydroepiandrosterone: is there a role for replacement? / Mayo Clin Proc 78 : 1257 ~ 1273
El-Maouche D / 2015 / Cortical bone mineral density in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency / Clin Endocrinol 82 : 330 ~ 337
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