지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 46 - 52 (7page)
이용수
초록· 키워드
오류제보하기
Objective The aim of this study is to investigate the association between oxidative stress and bone mineral density (BMD) accordingto menopausal status of Korean women.
Methods A total of 2,232 women who visited to the health promotion center at Pusan National University Hospital between 2010and 2014 were included in this cross-sectional study. Laboratory tests, such as uric acid, albumin, total bilirubin, which wereevaluated as a natural antioxidants. Homocysteine also was evaluated as a factor associated with oxidative stress. Correlationanalyses and partial correlation coefficient between BMD scores and laboratory parameters associated with oxidative stressaccording to menopausal status were performed with Pearson test.
Results By correlation analysis, uric acid had only positive correlation with femur and lumbar BMD in premenopausal andpostmenopausal group. But albumin and bilirubin, which were the other natural antioxidants, had no correlationwith BMD except total bilirubin with femur BMD in postmenopausal group. Homocysteine had negative correlationwith femur BMD in postmenopausal group. But there were different results in partial correlation coefficient adjustedby age and BMI. In premenopausal group, uric acid was still positive correlation with femur and lumbar BMD,whereas in postmenopausal group homocysteine had no correlation with femur BMD, total bilirubin and uric acidhad no correlation with lumbar BMD. At the multiple logistic regressions, only age and menopause status, uric acidhad correlation with BMD.
ConclusionIn this study, homocysteine had no correlation with BMD. But in natural antioxidant, uric acid had only positivecorrelation with BMD.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Ames BN. / 1981 / Uric acid provides an antioxidant defense in humans against oxidant-and radical-caused aging and cancer : a hypothesis / Proc Natl Acad Sci U S A 78 : 6858
Bai XC. / 2004 / Biochem Biophys Res Commun 314, 197-207 5. Lean JM, Davies JT, Fuller K, Jagger CJ, Kirstein B, Partington GA. A crucial role for thiol antioxidants in estro
Cao G. / 1998 / Comparison of different analytical methods for assessing total antioxidant capacity of human serum / Clin Chem 44 : 1309 ~ 1315
De Haan JB. / 1996 / Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is media
Eisman J. / 2004 / Osteoporosis prevalence and levels of treatment in primary care : the Australian BoneCare Study / J Bone Miner Res 19 : 1969 ~ 1975
Bai XC. / 2004 / Biochem Biophys Res Commun 314, 197-207 5. Lean JM, Davies JT, Fuller K, Jagger CJ, Kirstein B, Partington GA. A crucial role for thiol antioxidants in estro
Cao G. / 1998 / Comparison of different analytical methods for assessing total antioxidant capacity of human serum / Clin Chem 44 : 1309 ~ 1315
De Haan JB. / 1996 / Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is media
Eisman J. / 2004 / Osteoporosis prevalence and levels of treatment in primary care : the Australian BoneCare Study / J Bone Miner Res 19 : 1969 ~ 1975
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