지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 367 - 371 (5page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaIn bipolar disorder, dysregulation of mood may result from white matter abnormalities that change fiber tract length and fiber density. There are few studies evaluating the white matter microstructural changes in bipolar I patients (BD) with depressive episodes.
The present study aimed to evaluate anterior corona radiata in BD patients with depressive episode using Diffusion Tensor Imaging (DTI).
MethodsaaTwenty-one patients with bipolar depression and 19 healthy controls were investigated and groups were matched for age and gender. Diffusion-weighted echoplanar brain images (DW-EPI) were obtained using a 1.5 T MRI scanner. Regions of interest (ROIs) were manually placed on directional maps based on principal anisotropy. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values of white matter were measured in the anterior corona radiata (ACR) bilaterally by diffusion tensor imaging.
ResultsaaThere was not a significant difference between groups of age and gender (p>0.05). Significantly lower FA was observed in bilateral ACR in bipolar patients with depression compared with healthy individuals. And there is significantly higher ADC values in the left frontal corona radiate in bipolar patients.
ConclusionaaWhite matter abnormalities can be detected in patients with BD using DTI. The neuropathology of these abnormalities is unclear, but neuronal and axonal loss, myelin abnormalities and reduced white matter fiber density are likely to be relevant.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Adler CM / 2006 / Evidence of white matter pathology in bipolar disorder adolescents experiencing their first episode of mania: a diffusion tensor imaging study / Am J Psych
Akdemir A / 1996 / Validity, reliability and clinical use of Hamilton Depression Rating Scale / 3P J 4 : 251 ~ 259
Benedetti F / 2011 / Disruption of white matter integrity in bipolar depression as a possible structural marker of illness / Biol Psychiatry 69 : 309 ~ 317
Benedetti F / 2011 / Tract-specific white matter structural disruption in patients with bipolar disorder / Bipolar Disord 13 : 414 ~ 424
Berk M / 2009 / Early intervention in bipolar disorders: clinical, biochemical and neuroimaging imperatives / J Affect Disord 114 : 1 ~ 13
Akdemir A / 1996 / Validity, reliability and clinical use of Hamilton Depression Rating Scale / 3P J 4 : 251 ~ 259
Benedetti F / 2011 / Disruption of white matter integrity in bipolar depression as a possible structural marker of illness / Biol Psychiatry 69 : 309 ~ 317
Benedetti F / 2011 / Tract-specific white matter structural disruption in patients with bipolar disorder / Bipolar Disord 13 : 414 ~ 424
Berk M / 2009 / Early intervention in bipolar disorders: clinical, biochemical and neuroimaging imperatives / J Affect Disord 114 : 1 ~ 13
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