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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 118 - 124 (7page)
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초록· 키워드
오류제보하기
ObjectiveaaA relevant part of the social and personal burden caused by Bipolar Disorder (BD) is related to depressive phases. Authors investigated the genetic impact of a set of variations located in CRY1, a gene involved in the control of the circadian rhythms, towards depressive episodes in a sample of bipolar patients from the STEP-BD sample. As a secondary analysis, CYR1 variations were analyzed as predictors of sleep disruption.
Methodsaa654 bipolar patients were included in the analysis. Data were available genome-wide. The part of the genome coding for the CRY1 was imputed and pruned according to standards in the field. 7 SNPs were available for the analysis. A correction for multitesting was applied and we had sufficient power (0.80) to detect a small-medium effect size (0.22) between two allelic frequencies each one represented by at least 300 subjects.
ResultsaaIntronic rs10861688 was associated with the number of depressive events corrected for the times patients were assessed during the period of observation. In particular, AA subjects (n=21) had 4.46±3.15 events, AG (n=141) had 3.08±3.17 and GG (n=342) 2.65±2.97 (p=0.0048, beta=-0.22). No other significant associations were reported.
ConclusionaaWe bring further evidence that genes involved in the regulation of circadian rhythms may be relevant to depressive bipolar phases. Independent confirmation analyses are mandatory.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
[학술지(정기간행물)]
A Language and Environment for Statistical Computing / / A Language and Environment for Statistical Computing
Boland EM / 2013 / Sleep disturbance and cognitive deficits in bipolar disorder: toward an integrated examination of disorder maintenance and functional impairment / Clin Ps
Clements C / 2013 / Suicide in bipolar disorder in a national English sample, 1996-2009: frequency, trends and characteristics / Psychol Med 43 : 2593 ~ 2602
Coogan AN / 2011 / Chronotherapeutics and psychiatry: setting the clock to relieve the symptoms / World J Biol Psychiatry 12 (Suppl 1) : 40 ~ 43
A Language and Environment for Statistical Computing / / A Language and Environment for Statistical Computing
Boland EM / 2013 / Sleep disturbance and cognitive deficits in bipolar disorder: toward an integrated examination of disorder maintenance and functional impairment / Clin Ps
Clements C / 2013 / Suicide in bipolar disorder in a national English sample, 1996-2009: frequency, trends and characteristics / Psychol Med 43 : 2593 ~ 2602
Coogan AN / 2011 / Chronotherapeutics and psychiatry: setting the clock to relieve the symptoms / World J Biol Psychiatry 12 (Suppl 1) : 40 ~ 43
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