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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 205 - 215 (11page)
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초록· 키워드
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Objective: The aim of this study was to explore the prognostic values of biomarkers of neurodegeneration as measured by magnetic resonance imaging (MRI) and amyloid burden as measured by amyloid positron emission tomography (PET) in predicting conversion to Alzheimer’s disease (AD) in patients with mild cognitive impairment (MCI).
Methods: PubMed and EMBASE databases were searched for structural MRI or amyloid PET imaging studies published between January 2000 and July 2014 that reported conversion to AD in patients with MCI. Means and standard deviations or individual numbers of biomarkers with positive or negative status at baseline and corresponding numbers of patients who had progressed to AD at follow-up were retrieved from each study. The effect size of each biomarker was expressed as Hedges’s g.
Results: Twenty-four MRI studies and 8 amyloid PET imaging studies were retrieved. 674 of the 1741 participants (39%) developed AD. The effect size for predicting conversion to AD was 0.770 [95% confidence interval (CI) 0.607–0.934] for across MRI and 1.316 (95% CI 0.920–1.412) for amyloid PET imaging (p<0.001). The effect size was 1.256 (95% CI 0.902–1.609) for entorhinal cortex volume from MRI.
Conclusion: Our study suggests that volumetric MRI measurement may be useful for the early detection of AD.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Albert MS / 2011 / The diagnosis of mild cognitive impairment due to Alzheimer’s disease : recommendations from the National Institute on Aging-Alzheimer’s Association work
American Psychiatric Association / 1994 / Diagnostic and Statistical Manual of Mental Disorders: DSM-IV / American Psychiatric Association
Bakkour A / 2009 / The cortical signature of prodromal AD : regional thinning predicts mild AD dementia / Neurology 72 : 1048 ~ 1055
Caroli A / 2007 / Cerebral perfusion correlates of conversion to Alzheimer’s disease in amnestic mild cognitive impairment / J Neurol 254 : 1698 ~ 1707
Desikan RS / 2008 / MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD / Neurology 71 : 819 ~ 825
American Psychiatric Association / 1994 / Diagnostic and Statistical Manual of Mental Disorders: DSM-IV / American Psychiatric Association
Bakkour A / 2009 / The cortical signature of prodromal AD : regional thinning predicts mild AD dementia / Neurology 72 : 1048 ~ 1055
Caroli A / 2007 / Cerebral perfusion correlates of conversion to Alzheimer’s disease in amnestic mild cognitive impairment / J Neurol 254 : 1698 ~ 1707
Desikan RS / 2008 / MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD / Neurology 71 : 819 ~ 825
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