지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 904 - 912 (9page)
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초록· 키워드
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Purpose The aim of this study was to evaluate the role of radiotherapy (RT) in the management ofEwing sarcoma family tumors (ESFT).
Materials and MethodsRetrospective analysis was performed on 91 patients with localized ESFT treated from 1988to 2012. Primary tumor size was ! 8 cm in 33 patients. Surgery, RT, and combined surgerywith RT were applied in 37, 15, and 33 patients, respectively.
ResultsMedian follow-up was 43.8 months. Forty-three patients (47.3%) showed recurrence orprogressive disease. Twelve patients (13.2%) showed local failure after initial treatment.
Thirty-nine patients (42.9%) experienced distant metastases. The 5-year overall survival(OS), progression-free survival, and local control (LC) were 60.5%, 58.2%, and 85.1%,respectively. According to treatment, 5-year LC was 64.8% with RT and 90.2% with combinedsurgery and RT (p=0.052). Prognostic factors for OS were tumor size (! 8 cm, p < 0.001)and surgical resection (p < 0.001). In large tumors (! 8 cm), combined surgery and RTproduced better LC compared to RT (p=0.033). However, in smaller tumors (< 8 cm), RTwithout surgery resulted in a similar LC rate as RT with surgery (p=0.374).
ConclusionRT used for patients with unfavorable risk factors resulted in worse outcome than forpatients who received surgery. Smaller tumors could be controlled locally with chemotherapyand RT. For large tumors, combined surgery and RT is needed. Proper selection of localtreatment modality, RT, surgery, or both is crucial in the management of ESFT.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Bacci G / 1998 / Neoadjuvant chemotherapy for Ewing's sarcoma of bone: no benefit observed after adding ifosfamide and etoposide to vincristine, actinomycin, cyclophosphamide
Bacci G / 2009 / Treatment of nonmetastatic Ewing's sarcoma family tumors of the spine and sacrum : the experience from a single institution / Eur Spine J 18 : 1091 ~ 1095
Burgers JM / 1997 / Ewing's sarcoma of the pelvis : changes over 25 years in treatment and results / Eur J Cancer 33 : 2360 ~ 2367
Cotterill SJ / 2000 / Prognostic factors in Ewing's tumor of bone : analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group / J Clin Onc
Delattre O / 1994 / The Ewing family of tumors : a subgroup of smallround-cell tumors defined by specific chimeric transcripts / N Engl J Med 331 : 294 ~ 299
Bacci G / 2009 / Treatment of nonmetastatic Ewing's sarcoma family tumors of the spine and sacrum : the experience from a single institution / Eur Spine J 18 : 1091 ~ 1095
Burgers JM / 1997 / Ewing's sarcoma of the pelvis : changes over 25 years in treatment and results / Eur J Cancer 33 : 2360 ~ 2367
Cotterill SJ / 2000 / Prognostic factors in Ewing's tumor of bone : analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group / J Clin Onc
Delattre O / 1994 / The Ewing family of tumors : a subgroup of smallround-cell tumors defined by specific chimeric transcripts / N Engl J Med 331 : 294 ~ 299
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