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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 484 - 493 (10page)
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Purpose The effects of biological subtypes within breast cancer on prognosis are influenced by age at diagnosis. We investigated the association of young age with locoregional recurrence (LRR) between patients with luminal subtypes versus those with nonluminal subtypes.
Materials and Methods Medical records of 524 breast cancer patients with positive lymph nodes between 1999 and 2010 were reviewed retrospectively. All patients received curative surgery and adjuvant chemotherapy based on contemporary guidelines. Radiation was delivered for patients who underwent breast conserving surgery or those who had four or more positive lymph nodes after mastectomy. Adjuvant hormone therapy was administered to 413 patients with positive hormone receptors according to their menstrual status.
Results During median follow-up of 84 months, the 10-year locoregional recurrence-free survival rate (LRRFS) was 84.3% for all patients. Patients < 40 years showed significantly worse 10-year LRRFS than those 40 years (73.2% vs. 89.0%, respectively; p=0.01). The negative effect of young age on LRRFS was only observed in luminal subtypes (69.7% for < 40 years vs. 90.8% for 40 years; p < 0.01). Multivariate analysis using luminal subtypes 40 years as a reference revealed luminal subtypes < 40 years were significantly associated with increased risk of LRR (hazard ratio, 2.33; p < 0.01).
Conclusion Young breast cancer patients with positive lymph nodes had a higher risk of LRR than those aged 40 years. This detrimental effect of young age on LRR was confined in luminal subtypes.
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참고문헌 (21)
참고문헌 신청
Adami HO / 1986 / The relation between survival and age at diagnosis in breast cancer / N Engl J Med 315 : 559 ~ 563
Ahn SH / 2007 / Poor outcome of hormone receptor-positive breast cancer at very young age is due to tamoxifen resistance : nationwide survival data in Korea : a report from
Albain KS / 1994 / Breast cancer outcome and predictors of outc
Anders CK / 2008 / Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression / J Clin Oncol 26 :
Arvold ND / 2011 / Age, breast cancer subtype approximation, and local recurrence after breast-conserving therapy / J Clin Oncol 29 : 3885 ~ 3891
Ahn SH / 2007 / Poor outcome of hormone receptor-positive breast cancer at very young age is due to tamoxifen resistance : nationwide survival data in Korea : a report from
Albain KS / 1994 / Breast cancer outcome and predictors of outc
Anders CK / 2008 / Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression / J Clin Oncol 26 :
Arvold ND / 2011 / Age, breast cancer subtype approximation, and local recurrence after breast-conserving therapy / J Clin Oncol 29 : 3885 ~ 3891
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