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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 281 - 288 (8page)
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초록· 키워드
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During the last 15 years, traditional breast cancer classifications based on histopathology have been reorganized into the luminal A, luminal B, human epidermal growth factor receptor 2 (HER2), and basal-like subtypes based on gene expression profiling. Each molecular subtype has shown varying risk for progression, response to treatment, and survival outcomes. Research linking the imaging phenotype with the molecular subtype has revealed that non-calcified, relatively circumscribed masses with posterior acoustic enhancement are common in the basallike subtype, spiculated masses with a poorly circumscribed margin and posterior acoustic shadowing in the luminal subtype, and pleomorphic calcifications in the HER2-enriched subtype. Understanding the clinical implications of the molecular subtypes and imaging phenotypes could help radiologists guide precision medicine, tailoring medical treatment to patients and their tumor characteristics.
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등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Ng CK / 2015 / Breast cancer genomics from microarrays to massively parallel sequencing:paradigms and new insights / J Natl Cancer Inst 107:djv015
Cancer Genome Atlas Network / 2012 / Comprehensive molecular portraits of human breast tumours / Nature 490:61~70
Sorlie T / 2001 / Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications / Proc Natl Acad Sci U S A 98:10869~10874
Parker JS / 2009 / Supervised risk predictor of breast cancer based on intrinsic subtypes / J Clin Oncol 27:1160~1167
Goldhirsch A / 2013 / Personalizing the treatment of women with early breast cancer : highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013 / Ann Oncol 24:2206~2223
Cancer Genome Atlas Network / 2012 / Comprehensive molecular portraits of human breast tumours / Nature 490:61~70
Sorlie T / 2001 / Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications / Proc Natl Acad Sci U S A 98:10869~10874
Parker JS / 2009 / Supervised risk predictor of breast cancer based on intrinsic subtypes / J Clin Oncol 27:1160~1167
Goldhirsch A / 2013 / Personalizing the treatment of women with early breast cancer : highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013 / Ann Oncol 24:2206~2223
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