지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 518 - 526 (9page)
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초록· 키워드
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Purpose The purpose of this study was to evaluate potential prognostic factors in patients with adenoid cystic carcinoma (ACC).
Materials and Methods A total of 68 patients who underwent curative surgery and had available tissue were enrolled in this study. Their medical records and pathologic slides were reviewed and immunohistochemistry for basic fibroblast growth factor, fibroblast growth factor receptor (FGFR) 2, FGFR3, c-kit, Myb proto-oncogene protein, platelet-derived growth factor receptor beta, vascular endothelial growth factor (VEGF), and Ki-67 was performed. Univariate and multivariate analysis was performed for determination of disease-free survival (DFS) and overall survival (OS).
Results In univariate analyses, primary site of nasal cavity and paranasal sinus (p=0.022) and Ki-67 expression of more than 7% (p=0.001) were statistically significant factors for poor DFS. Regarding OS, perineural invasion (p=0.032), high expression of VEGF (p=0.033), and high expression of Ki-67 (p=0.007) were poor prognostic factors. In multivariate analyses, primary site of nasal cavity and paranasal sinus (p=0.028) and high expression of Ki-67 (p=0.004) were independent risk factors for poor DFS, and high expression of VEGF (p=0.011) and Ki-67 (p=0.011) showed independent association with poor OS.
Conclusion High expression of VEGF and Ki-67 were independent poor prognostic factors for OS in ACC.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Renehan A / 1996 / Long-term follow-up of over 1000 patients with salivary gland tumours treated in a single centre / Br J Surg 83:1750~1754
Gondivkar SM / 2011 / Adenoid cystic carcinoma : a rare clinical entity and literature review / Oral Oncol 47:231~236
Spiro RH / 1986 / Salivary neoplasms : overview of a 35-year experience with 2, 807 patients / Head Neck Surg 8:177~184
Sung MW / 2003 / Clinicopathologic predictors and impact of distant metastasis from adenoid cystic carcinoma of the head and neck / Arch Otolaryngol Head Neck Surg 129:1193~1197
Huang M / 1997 / Factors influencing survival rate in adenoid cystic carcinoma of the salivary glands / Int J Oral Maxillofac Surg 26:435~439
Gondivkar SM / 2011 / Adenoid cystic carcinoma : a rare clinical entity and literature review / Oral Oncol 47:231~236
Spiro RH / 1986 / Salivary neoplasms : overview of a 35-year experience with 2, 807 patients / Head Neck Surg 8:177~184
Sung MW / 2003 / Clinicopathologic predictors and impact of distant metastasis from adenoid cystic carcinoma of the head and neck / Arch Otolaryngol Head Neck Surg 129:1193~1197
Huang M / 1997 / Factors influencing survival rate in adenoid cystic carcinoma of the salivary glands / Int J Oral Maxillofac Surg 26:435~439
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