The correlation between serum vascular endothelial growth factor (VEGF) and tumor VEGF receptor 3 in colorectal cancer

André Goulart; Carla Ferreira; Ana Rodrigues; Barbara Coimbra; Nuno Sousa; Pedro Leão

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자료유형: 학술저널

저자정보: André Goulart (Hospital de Braga) Carla Ferreira (University of Minho) Ana Rodrigues (University of Minho) Barbara Coimbra (University of Minho) Nuno Sousa (University of Minho) Pedro Leão (Hospital de Braga)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.97 No.1

발행연도: 2019.7

수록면: 15 - 20 (6page)

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Purpose: Despite plasma biomarkers offering a number of advantages over tissue-based markers, the relationship between serum vascular endothelial growth factor (VEGF) and VEGF receptor (VEGF-R) tumor expression in colorectal cancer (CRC) is still unclear. This study was designed to establish the relationship between the concentration of serum VEGF and tumor VEGF-R expression in patients with CRC.
Methods: A prospective study of consecutive patients undergoing elective colorectal surgery during 1 year. Preoperative VEGF was determined by enzyme-linked immunosorbent assay and VEGF-R3 by immunochemistry.
Results: The initial sample included 134 patients with CRC diagnosis. Results showed significant association of serum values of VEGF with VEGF-R3 expression (P < 0.001), even in the presence of confounders (sex, age, body mass index, tumor location, and surgical approach). The estimated effect size was high (η<SUP>2</SUP> = 0.35).
Conclusion: Serum VEGF has a significant correlation with tumoral VEGF-R3 expression in CRC.

#Colorectal neoplasms #Vascular endothelial growth factors #Enzyme-linked immunosorbent assay #Immunohistochemistry

참고문헌 (26)

참고문헌 신청

Larijani LV / 2015 / Evaluation of VEGF immunohistochemical expression and correlation with clinicopathologic features in colorectal cancer / Govaresh 20:199~204

Al-Rawi MA / 2005 / Molecular and cellular mechanisms of lymphangiogenesis / Eur J Surg Oncol 31:117~121

Jurgensmeier JM / 2013 / Prognostic and predictive value of VEGF, sVEGFR-2 and CEA in mCRC studies comparing cediranib, bevacizumab and chemotherapy / Br J Cancer 108:1316~1323

Peng Y / 2012 / Expression of vascular endothelial growth factor can predict distant metastasis and diseasefree survival for clinical stage III rectal cancer following 30-Gy/10-f preoperative radiotherapy / Int J Colorectal Dis 27:1555~1560

Gupta VK / 2002 / Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance / Cancer J 8:47~54

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