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자료유형
학술저널
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대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제48권 제4호
발행연도
2016.1
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1,389 - 1,398 (10page)

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Purpose Breast cancer treatment has progressed significantly over the past 20 years. However, knowledge regarding male breast cancer (MBC) is sparse because of its rarity. This study is an investigation of the clinicopathologic features, treatments, and clinical outcomes of MBC. Materials and Methods Clinical records of 59 MBC patients diagnosed during 1995-2014 from seven institutions in Korea were reviewed retrospectively. Results Over a 20-year period, MBC patients accounted for 0.98% among total breast cancer patients, and increased every 5 years. The median age of MBC patients was 66 years (range, 24 to 87 years). Forty-three patients (73%) complained of a palpable breast mass initially. The median symptom duration was 5 months (range, 1 to 36 months). Mastectomy was performed in 96% of the patients. The most frequent histology was infiltrating ductal carcinoma (75%). Ninety-one percent of tumors (38/43) were estrogen receptor–positive, and 28% (11/40) showed epidermal growth factor receptor 2 (HER-2) overexpression. After curative surgery, 42% of patients (19/45) received adjuvant chemotherapy; 77% (27/35) received hormone therapy. Five out of ten patients with HER-2 overexpressing tumors did not receive adjuvant anti–HER-2 therapy, while two out of four patients with HER-2 overexpressing tumors received palliative trastuzumab for recurrent and metastatic disease. Letrozole was used for one patient in the palliative setting. The median overall survival durations were 7.2 years (range, 0.6 to 17.0 years) in patients with localized disease and 2.9 years (range, 0.6 to 4.3 years) in those with recurrent or metastatic disease. Conclusion Anti–HER-2 and hormonal therapy, except tamoxifen, have been underutilized in Korean MBC patients compared to female breast cancer patients. With the development of precision medicine, active treatment with targeted agents should be applied. Further investigation of the unique pathobiology of MBC is clinically warranted.
#Male breast neoplasms #Survival #Prognosis

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참고문헌 (24)

참고문헌 신청
Ravdin PM / 2007 / The decrease in breast-cancer incidence in 2003 in the United States / N Engl J Med 356:1670~1674 google schola Stang A / 2008 / Decline in breast cancer incidence in the United States : what about male breast cancer? / Breast Cancer Res Treat 112:595~596 google schola Speirs V / 2009 / The rising incidence of male breast cancer / Breast Cancer Res Treat 115:429~430 google schola Ministry of Health and Welfare; Korea Central Cancer Registry;National Cancer Center / 2012 / Annual report of cancer statistics in Korea in 2012 google schola Baek JM / 2005 / Male breast cancer / J Breast Cancer 8:123~127 google schola

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