지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 265 - 274 (10page)
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초록· 키워드
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Purpose Korean patients with prostate cancer (PC) typically present with a more aggressive disease than patients in Western populations. Consequently, it is unclear if the current criteria for active surveillance (AS) can safely be applied to Korean patients. Therefore, this study was conducted to define appropriate selection criteria for AS for patients with PC in Korea. Materials and Methods We conducted a multicenter retrospective study of 2,126 patients with low risk PC who actually underwent radical prostatectomy. The primary outcome was an unfavorable disease, which was defined by non-organ confined disease or an upgrading of the Gleason score to ! 7 (4+3). Predictive variables of an unfavorable outcome were identified by multivariate analysis using randomly selected training samples (n=1,623, 76.3%). We compared our selected criteria to various Western criteria for the primary outcome and validated our criteria using the remaining validation sample (n=503, 23.7%). Results A non-organ confined disease rate of 14.9% was identified, with an increase in Gleason score ! 7 (4+3) of 8.7% and a final unfavorable disease status of 20.8%. The following criteria were selected: Gleason score " 6, clinical stage T1-T2a, prostate-specific antigen (PSA) " 10 ng/mL, PSA density < 0.15 ng/mL/mL, number of positive cores " 2, and maximum cancer involvement in any one core " 20%. These criteria provided the lowest unfavorable disease rate (11.7%) when compared to Western criteria (13.3%-20.7%), and their validity was confirmed using the validation sample (5.9%). Conclusion We developed AS criteria which are appropriate for Korean patients with PC. Prospective studies using these criteria are now warranted.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Heidenreich A / 2014 / EAU guidelines on prostate cancer. Part 1: screening, diagnosis, and local treatment with curative intentupdate 2013 / Eur Urol 65:124~137
Mohler JL / 2014 / Prostate cancer, version 2.2014 / J Natl Compr Canc Netw. 12:686~718
Klotz L / 2015 / Long-term follow-up of a large active surveillance cohort of patients with prostate cancer / J Clin Oncol 33:272~277
D'Amico AV / 1998 / Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer / JAMA 280:969~974
변석수 / 2012 / Recent Changes in the Clinicopathologic Features of Korean Men with Prostate Cancer: A Comparison with Western Populations / Yonsei Medical Journal 53(3):543~549
Mohler JL / 2014 / Prostate cancer, version 2.2014 / J Natl Compr Canc Netw. 12:686~718
Klotz L / 2015 / Long-term follow-up of a large active surveillance cohort of patients with prostate cancer / J Clin Oncol 33:272~277
D'Amico AV / 1998 / Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer / JAMA 280:969~974
변석수 / 2012 / Recent Changes in the Clinicopathologic Features of Korean Men with Prostate Cancer: A Comparison with Western Populations / Yonsei Medical Journal 53(3):543~549
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