Exposure to Cerium Oxide Nanoparticles Is Associated With Activation of Mitogen-activated Protein Kinases Signaling and Apoptosis in Rat Lungs

Kevin M. Rice; Siva K. Nalabotu; Nandini D.P.K. Manne; Madhukar B. Kolli; Geeta Nandyala; Ravikumar Arvapalli; Jane Y. Ma; Eric R. Blough

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저자정보: Kevin M. Rice Siva K. Nalabotu Nandini D.P.K. Manne Madhukar B. Kolli Geeta Nandyala Ravikumar Arvapalli Jane Y. Ma Eric R. Blough

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제48권 제3호

발행연도: 2015.1

수록면: 132 - 141 (10page)

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Objectives: With recent advances in nanoparticle manufacturing and applications, potential exposure to nanoparticles in various settings is becoming increasing likely. No investigation has yet been performed to assess whether respiratory tract exposure to cerium oxide (CeO2) nanoparticles is associated with alterations in protein signaling, inflammation, and apoptosis in rat lungs. Methods: Specific-pathogen-free male Sprague-Dawley rats were instilled with either vehicle (saline) or CeO2 nanoparticles at a dosage of 7.0 mg/kg and euthanized 1, 3, 14, 28, 56, or 90 days after exposure. Lung tissues were collected and evaluated for the expression of proteins associated with inflammation and cellular apoptosis. Results: No change in lung weight was detected over the course of the study; however, cerium accumulation in the lungs, gross histological changes, an increased Bax to Bcl-2 ratio, elevated cleaved caspase-3 protein levels, increased phosphorylation of p38 MAPK, and diminished phosphorylation of ERK-1/2-MAPK were detected after CeO2 instillation (p<0.05). Conclusions: Taken together, these data suggest that high-dose respiratory exposure to CeO2 nanoparticles is associated with lung inflammation, the activation of signaling protein kinases, and cellular apoptosis, which may be indicative of a long-term localized inflammatory response.

#Cerium oxide nanoparticles #Lung #Inflammation #Mitogen-activated protein kinases

참고문헌 (23)

참고문헌 신청

[학술지(정

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Cassee FR / 2011 / Exposure, health and ecological effects review of engineered nanoscale cerium and cerium oxide associated with its use as a fuel additive / Crit Rev Toxic

Colon J / 2009 / Protection from radiation-induced pneumonitis using cerium oxide nanoparticles / Nanomedicine 5 (2) : 225 ~ 231

Das M / 2007 / Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons / Biomaterials 28 (10) : 1918 ~ 1925

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