Short-term Effect of Ambient Air Pollution on Emergency Department Visits for Diabetic Coma in Seoul, Korea

김현미; 김우진; 최지은; 김창수; 손정우

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자료유형: 학술저널

저자정보: 김현미 김우진 최지은 김창수 손정우

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제51권 제6호

발행연도: 2018.1

수록면: 265 - 274 (10page)

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Objectives: A positive association between air pollution and both the incidence and prevalence of diabetes mellitus (DM) has been reported in some epidemiologic and animal studies, but little research has evaluated the relationship between air pollution and diabetic coma. Diabetic coma is an acute complication of DM caused by diabetic ketoacidosis or hyperosmolar hyperglycemic state, which is characterized by extreme hyperglycemia accompanied by coma. We conducted a time-series study with a generalized additive model using a distributed-lag non-linear model to assess the association between ambient air pollution (particulate matter less than 10 μm in aerodynamic diameter, nitrogen dioxide [NO2], sulfur dioxide, carbon monoxide, and ozone) and emergency department (ED) visits for DM with coma in Seoul, Korea from 2005 to 2009. Methods: The ED data and medical records from the 3 years previous to each diabetic coma event were obtained from the Health Insurance Review and Assessment Service to examine the relationship with air pollutants. Results: Overall, the adjusted relative risks (RRs) for an interquartile range (IQR) increment of NO2 was statistically significant at lag 1 (RR, 1.125; 95% confidence interval [CI], 1.039 to 1.219) in a single-lag model and both lag 0-1 (RR, 1.120; 95% CI, 1.028 to 1.219) and lag 0-3 (RR, 1.092; 95% CI, 1.005 to 1.186) in a cumulative-lag model. In a subgroup analysis, significant positive RRs were found for females for per-IQR increments of NO2 at cumulative lag 0-3 (RR, 1.149; 95% CI, 1.022 to 1.291). Conclusions: The results of our study suggest that ambient air pollution, specifically NO2, is associated with ED visits for diabetic coma.

참고문헌 (36)

참고문헌 신청

Alderete TL / 2018 / Ambient and traffic-related air pollution exposures as novel risk factors for metabolic dysfunction and type 2 diabetes / Curr Epidemiol Rep 5(2):79~91

Renzi M / 2018 / Air pollution and occurrence of type 2 diabetes in a large cohort study / Environ Int 112:68~76

Dales RE / 2012 / Air pollution and hospitalization for acute complications of diabetes in Chile / Environ Int 46:1~5

Eze IC / 2015 / Association between ambient air pollution and diabetes mellitus in Europe and North America : systematic review and meta-analysis / Environ Health Perspect 123(5):381~389

Misra S / 2015 / Diabetic ketoacidosis in adults / BMJ 351:h5660

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