Diabetes Mellitus and Site-specific Colorectal Cancer Risk in Korea: A Case-control Study

우형택; 박지원; 박성찬; 신애선; 김정선; 오재환; Jeonghee Lee

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자료유형: 학술저널

저자정보: 우형택 박지원 박성찬 신애선 김정선 오재환 Jeonghee Lee

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제49권 제1호

발행연도: 2016.1

수록면: 45 - 52 (8page)

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Objectives: Previous large-scale cohort studies conducted in Korea have found a positive association between diabetes mellitus (DM) and colorectal cancer (CRC) in men only, in contrast to studies of other populations that have found significant associations in both men and women. Methods: A total of 1070 CRC cases and 2775 controls were recruited from the National Cancer Center, Korea between August 2010 and June 2013. Self-reported DM history and the duration of DM were compared between cases and controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by binary and polytomous logistic regression models. Results: DM was associated with an elevated risk of CRC in both men (OR, 1.47; 95% CI, 1.13 to 1.90) and women (OR, 1.92; 95% CI, 1.24 to 2.98). This association remained when we controlled for age, body mass index, alcohol consumption, and physical activity level. In sub-site analyses, DM was associated with distal colon cancer risk in both men (multivariate OR, 2.04; 95% CI, 1.39 to 3.00) and women (multivariate ORs, 1.99; 95% CI, 1.05 to 3.79), while DM was only associated with rectal cancer risk in women (multivariate OR, 2.05; 95% CI, 1.10 to 3.82). No significant association was found between DM and proximal colon cancer risk in either men (multivariate OR, 1.45; 95% CI, 0.88 to 2.41) or women (multivariate OR, 1.79; 95% CI, 0.78 to 4.08). Conclusions: Overall, DM was associated with an increased risk of CRC in Koreans. However, potential over-estimation of the ORs should be considered due to potential biases from the case-control design.

#Diabetes mellitus #Colorectal neoplasms #Colonic neoplasms

참고문헌 (40)

참고문헌 신청

Korea Central Cancer Registry, National Cancer Center / 2014 / Annual report of cancer statistics in Korea in 2012 :19

김대중 / 2011 / The Epidemiology of Diabetes in Korea / Diabetes and Metabolism Journal 35(4):303~308

Grundy SM / 1999 / Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association / Circulation 100(10):1134~1146

Shimoyama S / 2013 / Diabetes mellitus carries a risk of gastric cancer: a meta-analysis / World J Gastroenterol 19(40):6902~6910

Lee JY / 2013 / Diabetes mellitus as an independent risk factor for lung cancer: a meta-analysis of observational studies / Eur J Cancer 49(10):2411~2423

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