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논문 기본 정보

자료유형
학술저널
저자정보
박태현 (전북대학교 의과대학 소아과학교실) 김민선 (전북대학교) 이대열 (전북대학교)
저널정보
전남대학교 의과학연구소 전남의대학술지 전남의대학술지 제52권 제1호
발행연도
2016.1
수록면
64 - 69 (6page)

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We examined the clinical and laboratory characteristics of children newly diagnosedwith diabetes mellitus (DM) in a single-center study. We retrospectively reviewed thedata of 155 children with DM between January 2000 and December 2013. Of 155 diabeticchildren, 87 (56.1%) were diagnosed with type 1 DM (T1DM) and 68 (43.9%) withtype 2 DM (T2DM). Mean ages at diagnosis were 8.95±3.89 years (T1DM) and13.76±2.23 years (T2DM), respectively (p<0.001). There were significant differencesin HbA1c, C-peptide, and glutamic acid decarboxylase antibody levels between theT1DM and T2DM groups. Annual numbers of children with DM have increased, andsince 2011 the number of children with T2DM has surpassed the number with T1DM. The most common clinical symptom in T1DM was polyuria, and 26.4% of children withT1DM presented initially with diabetic ketoacidosis. In contrast, 60.3% of T2DM childrenshowed glucosuria in a school urine screening, and only 19.1% presented withpolydipsia. The rate of positivity for at least more than one islet autoantibody was 77.1%in T1DM and 26.3% in T2DM. Serum C-peptide levels in T2DM were increased up to12 months after onset and remained >3.59 ng/mL for 36 months. However, serumC-peptide levels in T1DM were slightly increased up to 6 months after onset and graduallydecreased to 0.32 ng/mL for 36 months. The prevalence of children with DM hasincreased over the last 14 years, and the proportion of T2DM patients has rapidly increasedsince 2009. Because childhood DM is associated with several metabolic andcardiovascular complications, children should be screened for early detection of DM,especially asymptomatic T2DM in children and adolescents.

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