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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 132 - 136 (5page)
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We report three patients with normal karyotype (NK) ALL, who showed genetic aberrations as determined by high-resolution single nucleotide polymorphism array (SNP-A) analysis at both diagnosis and relapse. We evaluated the clinical relevance of the SNP-A assay for the detection of subtle changes in the size of affected genetic lesions at relapse as well as the prognostic value of the assay. In our patients, application of the SNP-A assay enabled sensitive detection of cryptic changes affecting clinically important genes in NK ALL. Therefore, this assay seems to be more advantageous compared to other conventional methods such as FISH assay, HemaVision (DNA Technology, Denmark), and conventional karyotyping for the detection of an “unstable genotype” at relapse, which may be associated with microscopic clonal evolution and poor prognosis. Further comprehensive studies are required to confirm the issues presented by our case patients in this report.
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참고문헌 (9)
참고문헌 신청
Barresi V / 2010 / Broad copy neutral-loss of heterozygosity regions and rare recurring copy number abnormalities in normal karyotype-acute myeloid leukemia genomes / Genes C
Betts D / 2005 / del(13q) in ALL / Atlas Genet Cytogenet Oncol Haematol 9 : 24 ~ 25
Bullinger L / 2010 / Identification of acquired copy number alterations and uniparental disomies in cytogenetically normal acute myeloid leukemia using high-resolution single
Hahm C / 2014 / Genomic aberrations of myeloproliferative and myelodysplastic/myeloproliferative neoplasms in chronic phase and during disease progression / Int J Lab Hematol
Heerema NA / 1999 / 9p rearrangements in ALL / Atlas Genet Cytogenet Oncol Haematol 3 : 153 ~ 154
Betts D / 2005 / del(13q) in ALL / Atlas Genet Cytogenet Oncol Haematol 9 : 24 ~ 25
Bullinger L / 2010 / Identification of acquired copy number alterations and uniparental disomies in cytogenetically normal acute myeloid leukemia using high-resolution single
Hahm C / 2014 / Genomic aberrations of myeloproliferative and myelodysplastic/myeloproliferative neoplasms in chronic phase and during disease progression / Int J Lab Hematol
Heerema NA / 1999 / 9p rearrangements in ALL / Atlas Genet Cytogenet Oncol Haematol 3 : 153 ~ 154
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